| Ets-1 Transcription factor. Directly controls the expression of cytokine and chemokine genes in a wide variety of different cellular contexts. May control the differentiation, survival and proliferation of lymphoid cells. May also regulate angiogenesis through regulation of expression of genes controlling endothelial cell migration and invasion. Belongs to the ETS family. Highly expressed within lymphoid cells. Isoforms c-ETS-1A and Ets-1 p27 are both detected in all fetal tissues tested, but vary with tissue type in adult tissues. None is detected in brain or kidney. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB. |
| Protein type: DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor |
| Chromosomal Location of human Ortholog: 11q24.3 |
| Cellular Component: chromatin; cytoplasm; nucleoplasm; nucleus |
| Molecular Function: DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; identical protein binding; nuclear receptor coactivator activity; nucleic acid binding; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; transcription cis-regulatory region binding; transcription corepressor binding |
| Biological Process: cell differentiation; cell motility; immune response; negative regulation of cell population proliferation; PML body organization; positive regulation of angiogenesis; positive regulation of blood vessel endothelial cell migration; positive regulation of DNA-templated transcription; positive regulation of endothelial cell migration; positive regulation of erythrocyte differentiation; positive regulation of gene expression; positive regulation of inflammatory response; positive regulation of leukocyte adhesion to vascular endothelial cell; positive regulation of miRNA transcription; positive regulation of transcription by RNA polymerase II; regulation of angiogenesis; regulation of transcription by RNA polymerase II |
| Reference #: P14921 (UniProtKB) |
| Alt. Names/Synonyms: Avian erythroblastosis virus E26 (v-ets) oncogene homolog-1; c-ets-1; ets protein; ETS proto-oncogene 1, transcription factor; ETS-1; ETS1; EWSR2; FLJ10768; p54; Protein C-ets-1; v-ets avian erythroblastosis virus E2 oncogene homolog 1; v-ets avian erythroblastosis virus E26 oncogene homolog 1; v-ets erythroblastosis virus E26 oncogene homolog 1 (avian) |
| Gene Symbols: ETS1 |
| Molecular weight: 50,408 Da |
| Basal Isoelectric point: 5.04 Predict pI for various phosphorylation states |
| CST Pathways: B Cell Receptor Signaling | Growth And Differentiation Control by MAPKs | Regulation of P38 MAPKs |
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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Ets-1 |
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Cross-references to other databases:
AlphaFold
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STRING
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cBioPortal
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Wikipedia
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neXtProt
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Protein Atlas
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BioGPS
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Pfam
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