Ets-1 Transcription factor. Directly controls the expression of cytokine and chemokine genes in a wide variety of different cellular contexts. May control the differentiation, survival and proliferation of lymphoid cells. May also regulate angiogenesis through regulation of expression of genes controlling endothelial cell migration and invasion. Belongs to the ETS family. Highly expressed within lymphoid cells. Isoforms c-ETS-1A and Ets-1 p27 are both detected in all fetal tissues tested, but vary with tissue type in adult tissues. None is detected in brain or kidney. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor
Chromosomal Location of human Ortholog: 11q24.3
Cellular Component:  cytoplasm; nucleoplasm; nucleus; transcription factor complex
Molecular Function:  DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; histone acetyltransferase binding; identical protein binding; protein binding; RNA polymerase II proximal promoter sequence-specific DNA binding; transcription factor binding
Biological Process:  angiogenesis involved in wound healing; cell motility; cellular response to hydrogen peroxide; estrous cycle; female pregnancy; hypothalamus development; immune response; negative regulation of cell proliferation; negative regulation of inflammatory response; pituitary gland development; PML body organization; positive regulation of angiogenesis; positive regulation of blood vessel endothelial cell migration; positive regulation of cell proliferation; positive regulation of cellular component movement; positive regulation of endothelial cell migration; positive regulation of erythrocyte differentiation; positive regulation of gene expression; positive regulation of inflammatory response; positive regulation of leukocyte adhesion to vascular endothelial cell; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; pri-miRNA transcription by RNA polymerase II; regulation of angiogenesis; regulation of extracellular matrix disassembly; response to estradiol; response to hypoxia; response to interleukin-1; response to laminar fluid shear stress; response to mechanical stimulus
Reference #:  P14921 (UniProtKB)
Alt. Names/Synonyms: Avian erythroblastosis virus E26 (v-ets) oncogene homolog-1; c-ets-1; ets protein; ETS proto-oncogene 1, transcription factor; ETS-1; ETS1; EWSR2; FLJ10768; p54; Protein C-ets-1; v-ets avian erythroblastosis virus E2 oncogene homolog 1; v-ets avian erythroblastosis virus E26 oncogene homolog 1; v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)
Gene Symbols: ETS1
Molecular weight: 50,408 Da
Basal Isoelectric point: 5.04  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  Growth And Differentiation Control by MAPKs  |  Regulation of P38 MAPKs
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene