Ets-1 a proto-oncogenic transcription factor homologous to the v-ets erythroblastosis virus oncogene. The DNA binding activity of Ets1 is controlled by kinases and transcription factors. It contributes to the regulation of cellular differentiation in hematopoietic cells. Ets1 promotes invasive behavior in endothelial cells, vascular smooth muscle cells and epithelial cancer cells. Regulates the expression of MMP1, MMP3, MMP9 and uPA as well as of VEGF and VEGFR gene expression. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor
Chromosomal Location of Human Ortholog: 11q24.3
Cellular Component:  cytoplasm; nucleoplasm; nucleus; transcription factor complex
Molecular Function:  DNA binding; DNA binding transcription factor activity; histone acetyltransferase binding; identical protein binding; protein binding; transcription factor binding
Biological Process:  angiogenesis involved in wound healing; cell differentiation; cell motility; cellular response to hydrogen peroxide; female pregnancy; hypothalamus development; immune response; negative regulation of cell proliferation; negative regulation of inflammatory response; pituitary gland development; PML body organization and biogenesis; positive regulation of angiogenesis; positive regulation of blood vessel endothelial cell migration; positive regulation of cell proliferation; positive regulation of cellular component movement; positive regulation of endothelial cell migration; positive regulation of erythrocyte differentiation; positive regulation of gene expression; positive regulation of inflammatory response; positive regulation of leukocyte adhesion to vascular endothelial cell; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-templated; regulation of angiogenesis; regulation of extracellular matrix disassembly; regulation of transcription from RNA polymerase II promoter; response to estradiol; response to hypoxia; response to laminar fluid shear stress; response to mechanical stimulus
Reference #:  P14921 (UniProtKB)
Alt. Names/Synonyms: Avian erythroblastosis virus E26 (v-ets) oncogene homolog-1; ets protein; ETS-1; ETS1; EWSR2; FLJ10768; p54; Protein C-ets-1; v-ets avian erythroblastosis virus E2 oncogene homolog 1; v-ets avian erythroblastosis virus E26 oncogene homolog 1; v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)
Gene Symbols: ETS1
Molecular weight: 50,408 Da
Basal Isoelectric point: 5.04  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  Growth And Differentiation Control by MAPKs  |  Regulation of P38 MAPKs
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Ets-1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene