Ets-2 Transcription factor activating transcription. Binds specifically the DNA GGAA/T core motif (Ets-binding site or EBS) in gene promoters and stimulates transcription. Belongs to the ETS family. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Oncoprotein; Transcription factor
Chromosomal Location of human Ortholog: 21q22.2
Cellular Component:  chromatin; cytosol; nucleoplasm; nucleus; plasma membrane
Molecular Function:  DNA binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; nuclear glucocorticoid receptor binding; protein binding; protein domain specific binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; sequence-specific double-stranded DNA binding
Biological Process:  cell differentiation; ectodermal cell fate commitment; mesoderm development; negative regulation of transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II; primitive streak formation; regulation of transcription by RNA polymerase II; skeletal system development
Reference #:  P15036 (UniProtKB)
Alt. Names/Synonyms: ETS proto-oncogene 2, transcription factor; Ets-2; ETS2; ETS2IT1; oncogene ETS-2; Protein C-ets-2; v-ets avian erythroblastosis virus E2 oncogene homolog 2; v-ets avian erythroblastosis virus E26 oncogene homolog 2; v-ets erythroblastosis virus E26 oncogene homolog 2; v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)
Gene Symbols: ETS2
Molecular weight: 53,001 Da
Basal Isoelectric point: 4.93  Predict pI for various phosphorylation states
CST Pathways:  Growth And Differentiation Control by MAPKs
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Ets-2

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein