IL12A
Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-6 superfamily. Note: This description may include information from UniProtKB.
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Protein type: Cytokine; Secreted; Secreted, signal peptide |
Chromosomal Location of mouse Ortholog: 3 E1|3 31.92 cM |
Cellular Component:
cell surface; cytoplasm; endoplasmic reticulum lumen; endosome lumen; extracellular region; extracellular space; Golgi lumen; interleukin-12 complex; interleukin-12 receptor complex
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Molecular Function:
cytokine activity; growth factor activity; interleukin-12 beta subunit binding; interleukin-12 receptor binding; interleukin-27 binding; protein binding; protein heterodimerization activity
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Biological Process:
cell migration; cell population proliferation; cellular response to lipopolysaccharide; cellular response to virus; defense response to protozoan; extrinsic apoptotic signaling pathway; immune response; interleukin-12-mediated signaling pathway; negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis; negative regulation of interleukin-17 production; negative regulation of protein secretion; negative regulation of smooth muscle cell proliferation; negative regulation of vascular endothelial growth factor signaling pathway; positive regulation of cell adhesion; positive regulation of dendritic cell chemotaxis; positive regulation of lymphocyte proliferation; positive regulation of mononuclear cell proliferation; positive regulation of natural killer cell activation; positive regulation of natural killer cell mediated cytotoxicity; positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target; positive regulation of natural killer cell proliferation; positive regulation of NK T cell activation; positive regulation of NK T cell proliferation; positive regulation of receptor signaling pathway via JAK-STAT; positive regulation of smooth muscle cell apoptotic process; positive regulation of T cell differentiation; positive regulation of T cell mediated cytotoxicity; positive regulation of T cell proliferation; positive regulation of type II interferon production; positive regulation of tyrosine phosphorylation of STAT protein; response to lipopolysaccharide; response to UV-B; T cell proliferation; T-helper 1 cell activation; T-helper 1 cell cytokine production; type II interferon production
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Reference #:
P43431
(UniProtKB)
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Alt. Names/Synonyms: CLMF p35; Cytotoxic lymphocyte maturation factor 35 kDa subunit; IL-12; IL-12 p35 subunit; IL-12 subunit p35; IL-12A; IL-12p35; Il12a; interleukin 12a; interleukin 12a p35 subunit; interleukin-12 p35 subunit; Interleukin-12 subunit alpha; Ll12a; MGC151228; MGC151232; p35
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Gene Symbols: Il12a
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Molecular weight:
24,179 Da
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Basal Isoelectric point:
8.4
Predict pI for various phosphorylation states
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