IL12A Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-6 superfamily. Note: This description may include information from UniProtKB.
Protein type: Cytokine; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 3 E1|3 31.92 cM
Cellular Component:  cell surface; cytoplasm; extracellular region; extracellular space; interleukin-12 complex
Molecular Function:  interleukin-12 beta subunit binding; interleukin-12 receptor binding; interleukin-27 binding; protein binding; protein heterodimerization activity
Biological Process:  cell cycle arrest; cell migration; cell proliferation; cellular response to lipopolysaccharide; cellular response to virus; defense response to protozoan; extrinsic apoptotic signaling pathway; immune response; interferon-gamma production; negative regulation of interleukin-17 production; negative regulation of smooth muscle cell proliferation; positive regulation of cell adhesion; positive regulation of dendritic cell chemotaxis; positive regulation of interferon-gamma production; positive regulation of lymphocyte proliferation; positive regulation of mononuclear cell proliferation; positive regulation of natural killer cell activation; positive regulation of natural killer cell mediated cytotoxicity; positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target; positive regulation of NK T cell activation; positive regulation of smooth muscle cell apoptotic process; positive regulation of T cell differentiation; positive regulation of T cell mediated cytotoxicity; positive regulation of T cell proliferation; positive regulation of tyrosine phosphorylation of STAT protein; response to lipopolysaccharide; response to UV-B; T-helper 1 cell activation; T-helper 1 cell cytokine production
Reference #:  P43431 (UniProtKB)
Alt. Names/Synonyms: CLMF p35; Cytotoxic lymphocyte maturation factor 35 kDa subunit; IL-12 subunit p35; IL-12A; IL-12p35; Il12a; interleukin 12a; interleukin 12a p35 subunit; Interleukin-12 subunit alpha; Ll12a; MGC151228; MGC151232; p35
Gene Symbols: Il12a
Molecular weight: 24,179 Da
Basal Isoelectric point: 8.4  Predict pI for various phosphorylation states
Select Structure to View Below

IL12A

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene