Huntingtin Huntingtin: May play a role in microtubule-mediated transport or vesicle function. Huntingtin, myristoylated N-terminal fragment: Promotes the formation of autophagic vesicles. Belongs to the huntingtin family. Expressed in the brain cortex (at protein level). Widely expressed with the highest level of expression in the brain (nerve fibers, varicosities, and nerve endings). In the brain, the regions where it can be mainly found are the cerebellar cortex, the neocortex, the striatum, and the hippocampal formation. Note: This description may include information from UniProtKB.

Protein type: Cytoskeletal

Chromosomal Location of human Ortholog: 4p16.3

Cellular Component: autophagosome; axon; centriole; cytoplasm; cytoplasmic vesicle membrane; cytosol; dendrite; early endosome; endoplasmic reticulum; Golgi apparatus; inclusion body; late endosome; nucleoplasm; nucleus; perinuclear region of cytoplasm; postsynaptic cytosol; presynaptic cytosol; protein-containing complex

Molecular Function: beta-tubulin binding; dynactin binding; dynein intermediate chain binding; heat shock protein binding; identical protein binding; kinase binding; p53 binding; profilin binding; protein binding; transmembrane transporter binding

Biological Process: apoptotic process; establishment of mitotic spindle orientation; Golgi organization; microtubule-based transport; negative regulation of extrinsic apoptotic signaling pathway; positive regulation of aggrephagy; positive regulation of apoptotic process; positive regulation of autophagy of mitochondrion; positive regulation of cilium assembly; positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; positive regulation of lipophagy; protein destabilization; regulation of CAMKK-AMPK signaling cascade; regulation of cAMP-dependent protein kinase activity; regulation of phosphoprotein phosphatase activity; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; vesicle transport along microtubule; vocal learning

Disease: Huntington Disease; Lopes-maciel-rodan Syndrome

Reference #: P42858 (UniProtKB)

Alt. Names/Synonyms: HD; HD protein; HTT; Huntingtin; Huntingtin, myristoylated N-terminal fragment; Huntington disease protein; IT15; LOMARS

Gene Symbols: HTT

Molecular weight: 347,603 Da

Basal Isoelectric point: 5.81 Predict pI for various phosphorylation states

CST Pathways: PI3K/Akt Signaling

Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology^®

Select Structure to View Below
Huntingtin

Get PyMOL Script Get Chimera Script