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CR2
Receptor for complement C3, for the Epstein-Barr virus on human B-cells and T-cells and for HNRNPU. Participates in B lymphocytes activation. (Microbial infection) Acts as a receptor for Epstein-Barr virus. Belongs to the receptors of complement activation (RCA) family. Mature B-lymphocytes, T-lymphocytes, pharyngeal epithelial cells, astrocytes and follicular dendritic cells of the spleen. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Membrane protein, integral; Receptor, misc. |
| Chromosomal Location of mouse Ortholog: 1 H6|1 98.44 cM |
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Cellular Component:
cell surface; external side of plasma membrane; extracellular space; membrane; plasma membrane; receptor complex
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Molecular Function:
complement binding; complement receptor activity; DNA binding; immunoglobulin receptor binding; protein binding; protein homodimerization activity; signaling receptor activity
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Biological Process:
B cell differentiation; B cell proliferation; bone development; cartilage development; cellular response to lipopolysaccharide; complement activation, alternative pathway; complement activation, classical pathway; immune system process; immunoglobulin mediated immune response; inflammatory response; innate immune response; negative regulation of complement activation, classical pathway; T cell mediated immunity
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Reference #:
P19070
(UniProtKB)
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Alt. Names/Synonyms: C3D; C3DR; CD21; CD35; Complement C3d receptor; complement receptor 2; complement receptor type 1; Complement receptor type 2; Cr-; Cr-1; Cr-2; Cr1; Cr2; expressed in B lymphocytes; MGC130295
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Gene Symbols: Cr2
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Molecular weight:
112,995 Da
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Basal Isoelectric point:
7.22
Predict pI for various phosphorylation states
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