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ICAM2
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance. Belongs to the immunoglobulin superfamily. ICAM family. Note: This description may include information from UniProtKB.
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| Protein type: Cell adhesion; Membrane protein, integral |
| Chromosomal Location of mouse Ortholog: 11 E1|11 69.09 cM |
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Cellular Component:
cell periphery; cell projection; cleavage furrow; membrane; microvillus; plasma membrane; uropod
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Molecular Function:
integrin binding; protein binding
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Biological Process:
cell adhesion; cell-cell adhesion
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Reference #:
P35330
(UniProtKB)
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Alt. Names/Synonyms: CD102; Icam; ICAM-2; Icam2; Intercellular adhesion molecule 2; Ly-60; Lymphocyte function-associated AG-1 counter-receptor; OTTMUSP00000003460; OTTMUSP00000003463
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Gene Symbols: Icam2
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Molecular weight:
31,390 Da
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Basal Isoelectric point:
8.1
Predict pI for various phosphorylation states
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