DPEP1 Hydrolyzes a wide range of dipeptides. Implicated in the renal metabolism of glutathione and its conjugates. Converts leukotriene D4 to leukotriene E4; it may play an important role in the regulation of leukotriene activity. Belongs to the peptidase M19 family. Note: This description may include information from UniProtKB.
Protein type: EC; Membrane protein, GPI anchor; Protease
Chromosomal Location of Human Ortholog: 16q24.3
Cellular Component:  apical part of cell; apical plasma membrane; cell junction; extracellular space; microvillus membrane; nucleus; plasma membrane
Molecular Function:  caspase inhibitor activity; dipeptidase activity; dipeptidyl-peptidase activity; metalloexopeptidase activity; protein binding; zinc ion binding
Biological Process:  antibiotic metabolic process; apoptosis; glutathione metabolic process; homocysteine metabolic process; leukotriene metabolic process; negative regulation of apoptosis; negative regulation of cell migration; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; proteolysis; xenobiotic metabolic process
Reference #:  P16444 (UniProtKB)
Alt. Names/Synonyms: Dehydropeptidase-I; Dipeptidase 1; dipeptidase 1 (renal); DPEP1; hRDP; MBD1; MDP; Microsomal dipeptidase; RDP; Renal dipeptidase
Gene Symbols: DPEP1
Molecular weight: 45,674 Da
Basal Isoelectric point: 5.75  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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