CYP2R1 Has a D-25-hydroxylase activity on both forms of vitamin D, vitamin D(2) and D(3). Belongs to the cytochrome P450 family. Note: This description may include information from UniProtKB.
Protein type: EC 1.14.13.15; Oxidoreductase
Chromosomal Location of mouse Ortholog: 7|7 F1
Cellular Component:  cytoplasm; endoplasmic reticulum; intracellular membrane-bounded organelle; membrane
Molecular Function:  heme binding; iron ion binding; metal ion binding; monooxygenase activity; oxidoreductase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; steroid hydroxylase activity; vitamin D3 25-hydroxylase activity
Biological Process:  calcitriol biosynthetic process from calciol; exogenous drug catabolic process; organic acid metabolic process; oxidation-reduction process; vitamin D metabolic process; xenobiotic metabolic process
Reference #:  Q6VVW9 (UniProtKB)
Alt. Names/Synonyms: CP2R1; Cyp2r1; Cytochrome P450 2R1; cytochrome P450, 2r1; cytochrome P450, family 2, subfamily r, polypeptide 1; MGC124198; MGC124199; Vitamin D 25-hydroxylase
Gene Symbols: Cyp2r1
Molecular weight: 57,313 Da
Basal Isoelectric point: 7.29  Predict pI for various phosphorylation states
Select Structure to View Below

CYP2R1

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene