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COL18A1
Probably plays a major role in determining the retinal structure as well as in the closure of the neural tube. Non-collagenous domain 1: May regulate extracellular matrix-dependent motility and morphogenesis of endothelial and non-endothelial cells; the function requires homotrimerization and implicates MAPK signaling. Endostatin: Potently inhibits endothelial cell proliferation and angiogenesis. May inhibit angiogenesis by binding to the heparan sulfate proteoglycans involved in growth factor signaling. Inhibits VEGFA-induced endothelial cell proliferation and migration. Seems to inhibit VEGFA-mediated signaling by blocking the interaction of VEGFA to its receptor KDR/VEGFR2. Modulates endothelial cell migration in an integrin-dependent manner implicating integrin ITGA5:ITGB1 and to a lesser extent ITGAV:ITGB3 and ITGAV:ITGB5. May negatively regulate the activity of homotrimeric non-collagenous domain 1. Belongs to the multiplexin collagen family. Present in multiple organs with highest levels in liver, lung and kidney. 3 human isoforms generated by alternative promoter usage or alternative splicing have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Secreted; Secreted, signal peptide |
| Chromosomal Location of mouse Ortholog: 10 C1|10 39.72 cM |
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Cellular Component:
basement membrane; collagen trimer; collagen-containing extracellular matrix; extracellular region; extracellular space
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Molecular Function:
extracellular matrix structural constituent conferring tensile strength; identical protein binding; metal ion binding; protein binding
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Biological Process:
angiogenesis; blood vessel endothelial cell migration; cell adhesion; collagen fibril organization; endothelial cell apoptotic process; endothelial cell morphogenesis; extracellular matrix organization; notochord development; positive regulation of blood vessel endothelial cell migration; positive regulation of endothelial cell apoptotic process; positive regulation of vascular endothelial cell proliferation; skeletal system development; vascular endothelial cell proliferation
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Reference #:
P39061
(UniProtKB)
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Alt. Names/Synonyms: alpha-1(XVIII) collagen; COIA1; Col18a1; Collagen alpha-1(XVIII) chain; collagen, type XVIII, alpha 1; endo; Endostatin; NC1; Non-collagenous domain 1; OTTMUSP00000023764; procollagen, type XVIII, alpha 1
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Gene Symbols: Col18a1
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Molecular weight:
182,172 Da
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Basal Isoelectric point:
5.39
Predict pI for various phosphorylation states
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