COL18A1 Probably plays a major role in determining the retinal structure as well as in the closure of the neural tube. Non-collagenous domain 1: May regulate extracellular matrix-dependent motility and morphogenesis of endothelial and non-endothelial cells; the function requires homotrimerization and implicates MAPK signaling. Endostatin: Potently inhibits endothelial cell proliferation and angiogenesis. May inhibit angiogenesis by binding to the heparan sulfate proteoglycans involved in growth factor signaling. Inhibits VEGFA-induced endothelial cell proliferation and migration. Seems to inhibit VEGFA-mediated signaling by blocking the interaction of VEGFA to its receptor KDR/VEGFR2. Modulates endothelial cell migration in an integrin-dependent manner implicating integrin ITGA5:ITGB1 and to a lesser extent ITGAV:ITGB3 and ITGAV:ITGB5. May negatively regulate the activity of homotrimeric non-collagenous domain 1. Belongs to the multiplexin collagen family. Present in multiple organs with highest levels in liver, lung and kidney. 3 human isoforms generated by alternative promoter usage or alternative splicing have been reported. Note: This description may include information from UniProtKB.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 10 C1|10 39.72 cM
Cellular Component:  basement membrane; collagen trimer; extracellular matrix; extracellular region; extracellular space
Molecular Function:  extracellular matrix structural constituent; extracellular matrix structural constituent conferring tensile strength; metal ion binding; structural molecule activity
Biological Process:  angiogenesis; cell adhesion; endothelial cell morphogenesis; extracellular matrix organization; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of endothelial cell apoptotic process
Reference #:  P39061 (UniProtKB)
Alt. Names/Synonyms: alpha-1(XVIII) collagen; COIA1; Col18a1; Collagen alpha-1(XVIII) chain; collagen, type XVIII, alpha 1; endo; Endostatin; NC1; Non-collagenous domain 1; OTTMUSP00000023764; procollagen, type XVIII, alpha 1
Gene Symbols: Col18a1
Molecular weight: 182,172 Da
Basal Isoelectric point: 5.39  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene