COL18A1 Probably plays a major role in determining the retinal structure as well as in the closure of the neural tube. Non-collagenous domain 1: May regulate extracellular matrix-dependent motility and morphogenesis of endothelial and non-endothelial cells; the function requires homotrimerization and implicates MAPK signaling. Endostatin: Potently inhibits endothelial cell proliferation and angiogenesis. May inhibit angiogenesis by binding to the heparan sulfate proteoglycans involved in growth factor signaling. Inhibits VEGFA-induced endothelial cell proliferation and migration. Seems to inhibit VEGFA-mediated signaling by blocking the interaction of VEGFA to its receptor KDR/VEGFR2. Modulates endothelial cell migration in an integrin-dependent manner implicating integrin ITGA5:ITGB1 and to a lesser extent ITGAV:ITGB3 and ITGAV:ITGB5. May negatively regulate the activity of homotrimeric non-collagenous domain 1. Belongs to the multiplexin collagen family. Present in multiple organs with highest levels in liver, lung and kidney. 3 human isoforms generated by alternative promoter usage or alternative splicing have been reported. Note: This description may include information from UniProtKB.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 21q22.3
Cellular Component:  basement membrane; collagen trimer; endoplasmic reticulum lumen; extracellular region
Molecular Function:  extracellular matrix structural constituent conferring tensile strength; metal ion binding
Biological Process:  angiogenesis; animal organ morphogenesis; cell adhesion; endothelial cell morphogenesis; extracellular matrix organization; negative regulation of cell proliferation; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of endothelial cell apoptotic process; response to drug; response to hydrostatic pressure; visual perception
Disease: Glaucoma, Primary Closed-angle; Knobloch Syndrome 1
Reference #:  P39060 (UniProtKB)
Alt. Names/Synonyms: antiangiogenic agent; COIA1; COL18A1; Collagen alpha-1(XVIII) chain; collagen type XVIII alpha 1 chain; collagen, type XVIII, alpha 1; Endostatin; FLJ27325; FLJ34914; GLCC; KNO; KNO1; KS; MGC74745; multi-functional protein MFP; NC1; Non-collagenous domain 1
Gene Symbols: COL18A1
Molecular weight: 178,188 Da
Basal Isoelectric point: 5.67  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB