C8B Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. Belongs to the complement C6/C7/C8/C9 family. Note: This description may include information from UniProtKB.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 4 C6|4 48.61 cM
Cellular Component:  extracellular region; extracellular space; membrane attack complex
Molecular Function:  protein-containing complex binding
Biological Process:  complement activation; complement activation, alternative pathway; complement activation, classical pathway; cytolysis; immune response; immune system process; innate immune response
Reference #:  Q8BH35 (UniProtKB)
Alt. Names/Synonyms: 4930439B20Rik; AI595927; C8b; CO8B; Complement component 8 subunit beta; complement component 8, beta polypeptide; complement component 8, beta subunit; Complement component C8 beta chain; OTTMUSP00000008473
Gene Symbols: C8b
Molecular weight: 66,229 Da
Basal Isoelectric point: 8.07  Predict pI for various phosphorylation states
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C8B

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene