E2F5 Transcriptional activator that binds to E2F sites, these sites are present in the promoter of many genes whose products are involved in cell proliferation. May mediate growth factor-initiated signal transduction. It is likely involved in the early responses of resting cells to growth factor stimulation. Specifically required for multiciliate cell differentiation: together with MCIDAS and E2F5, binds and activate genes required for centriole biogenesis. Belongs to the E2F/DP family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 3|3 A1
Cellular Component:  cytoplasm; fibrillar center; nuclear envelope; nucleolus; nucleus; RNA polymerase II transcription factor complex; sarcoplasm; transcription factor complex
Molecular Function:  DNA binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; protein binding; protein dimerization activity; sequence-specific DNA binding; transcription factor binding
Biological Process:  animal organ morphogenesis; cell projection organization; G1/S transition of mitotic cell cycle; negative regulation of transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II; regulation of cell cycle; regulation of transcription, DNA-templated
Reference #:  Q61502 (UniProtKB)
Alt. Names/Synonyms: AU024671; E2F transcription factor 5; E2F-5; E2f5; Transcription factor E2F5
Gene Symbols: E2f5
Molecular weight: 36,555 Da
Basal Isoelectric point: 4.95  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling  |  G1/S Checkpoint
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene