GTP-binding protein that has very low efficiency as allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Can activate phospholipase D with very low efficiency. Important for normal function of the Golgi apparatus. Belongs to the small GTPase superfamily. Arf family. Detected in heart, liver, lung and liver (at protein level). Detected in fetal heart, lung, liver and kidney. Detected in adult heart, placenta, lung, liver, skeletal muscle, kidney and pancreas. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: G protein; G protein, monomeric; G protein, monomeric, ARF
Molecular Function: enzyme activator activity; GTP binding; GTPase activity; metal ion binding; protein domain specific binding
Biological Process: activation of phospholipase D activity; Golgi organization; Golgi vesicle transport; protein localization to Golgi apparatus; retrograde transport, endosome to Golgi; toxin metabolic process