ARL1 GTP-binding protein that has very low efficiency as allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Can activate phospholipase D with very low efficiency. Important for normal function of the Golgi apparatus. Belongs to the small GTPase superfamily. Arf family. Detected in heart, liver, lung and liver (at protein level). Detected in fetal heart, lung, liver and kidney. Detected in adult heart, placenta, lung, liver, skeletal muscle, kidney and pancreas. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: G protein; G protein, monomeric; G protein, monomeric, ARF
Chromosomal Location of Human Ortholog: 12q23.2
Cellular Component:  cytoplasm; cytosol; Golgi apparatus; trans-Golgi network; trans-Golgi network membrane
Molecular Function:  enzyme activator activity; GTP binding; GTPase activity; metal ion binding; protein domain specific binding
Biological Process:  activation of phospholipase D activity; Golgi organization; Golgi vesicle transport; protein localization to Golgi apparatus; retrograde transport, endosome to Golgi; toxin metabolic process
Reference #:  P40616 (UniProtKB)
Alt. Names/Synonyms: ADP-ribosylation factor-like 1; ADP-ribosylation factor-like protein 1; ARFL1; ARL1
Gene Symbols: ARL1
Molecular weight: 20,418 Da
Basal Isoelectric point: 5.63  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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