B4GALT4
Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. Belongs to the glycosyltransferase 7 family. High expression in heart, placenta, kidney and pancreas; lower in brain, colon, lung, muscle, ovary, testis and uterus. Note: This description may include information from UniProtKB.
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Protein type: EC 2.4.1.275; EC 2.4.1.90; Glycan Metabolism - glycosphingolipid biosynthesis - lacto and neolacto series; Glycan Metabolism - keratan sulfate biosynthesis; Membrane protein, integral; Transferase |
Chromosomal Location of human Ortholog: 3q13.32 |
Cellular Component:
extracellular region; Golgi apparatus; Golgi membrane; membrane
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Molecular Function:
galactosyltransferase activity; metal ion binding; N-acetyllactosamine synthase activity; protein binding; UDP-galactosyltransferase activity
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Biological Process:
carbohydrate metabolic process; glycosylation; keratan sulfate biosynthetic process; lactosylceramide biosynthetic process; membrane lipid metabolic process; protein glycosylation
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Reference #:
O60513
(UniProtKB)
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Alt. Names/Synonyms: b4Gal-T4; B4GALT4; B4GT4; Beta-1,4-galactosyltransferase 4; Beta-1,4-GalTase 4; Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase; beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase 4; Beta4Gal-T4; Lactotriaosylceramide beta-1,4-galactosyltransferase; N-acetyllactosamine synthase; Nal synthase; UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 4; UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase 4; UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4; UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 4
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Gene Symbols: B4GALT4
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Molecular weight:
40,041 Da
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Basal Isoelectric point:
9.18
Predict pI for various phosphorylation states
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