ATP1B1 This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Transporter
Chromosomal Location of Human Ortholog: 1 H2.2|1 71.75 cM
Cellular Component:  apical plasma membrane; basolateral plasma membrane; caveola; integral component of membrane; intercalated disc; membrane; plasma membrane; sarcolemma; sodium:potassium-exchanging ATPase complex
Molecular Function:  ATPase activator activity; ATPase binding; protein binding; protein C-terminus binding; protein kinase binding; sodium:potassium-exchanging ATPase activity
Biological Process:  ATP metabolic process; blastocyst development; cardiac muscle contraction; cell adhesion; cellular calcium ion homeostasis; cellular potassium ion homeostasis; cellular sodium ion homeostasis; ion transport; membrane repolarization; metal ion transport; positive regulation of ATPase activity; positive regulation of calcium:sodium antiporter activity; positive regulation of potassium ion import; positive regulation of potassium ion transmembrane transporter activity; positive regulation of sodium ion export across plasma membrane; potassium ion import across plasma membrane; potassium ion transport; protein localization to plasma membrane; protein stabilization; regulation of calcium ion transmembrane transport; regulation of cardiac muscle contraction by calcium ion signaling; regulation of gene expression; relaxation of cardiac muscle; response to hypoxia; sodium ion export across plasma membrane; sodium ion transport
Reference #:  P14094 (UniProtKB)
Alt. Names/Synonyms: AT1B1; Atp1b1; Atp4b; ATPase, Na+/K+ transporting, beta 1 polypeptide; Atpb; Atpb-1; sodium/potassium ATPase beta subunit; Sodium/potassium-dependent ATPase subunit beta-1; Sodium/potassium-transporting ATPase subunit beta-1
Gene Symbols: Atp1b1
Molecular weight: 35,195 Da
Basal Isoelectric point: 8.83  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene