ATP1B1 This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. Involved in cell adhesion and establishing epithelial cell polarity. Belongs to the X(+)/potassium ATPases subunit beta family. Found in most tissues. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Transporter
Chromosomal Location of human Ortholog: 1q24.2
Cellular Component:  apical plasma membrane; basolateral plasma membrane; caveola; intercalated disc; membrane; plasma membrane; sarcolemma; sodium:potassium-exchanging ATPase complex
Molecular Function:  ATPase activator activity; ATPase binding; protein binding; protein C-terminus binding; protein kinase binding
Biological Process:  ATP metabolic process; cardiac muscle contraction; cell adhesion; cell communication by electrical coupling involved in cardiac conduction; cellular calcium ion homeostasis; cellular potassium ion homeostasis; cellular sodium ion homeostasis; establishment or maintenance of transmembrane electrochemical gradient; ion transmembrane transport; leukocyte migration; membrane repolarization; membrane repolarization during cardiac muscle cell action potential; positive regulation of ATPase activity; positive regulation of calcium:sodium antiporter activity; positive regulation of potassium ion import; positive regulation of potassium ion transmembrane transporter activity; positive regulation of sodium ion export across plasma membrane; potassium ion import across plasma membrane; protein localization to plasma membrane; protein stabilization; protein transport into plasma membrane raft; regulation of cardiac conduction; regulation of cardiac muscle contraction by calcium ion signaling; regulation of gene expression; relaxation of cardiac muscle; response to hypoxia; sodium ion export across plasma membrane
Disease: Hypertension, Essential
Reference #:  P05026 (UniProtKB)
Alt. Names/Synonyms: adenosinetriphosphatase; AT1B1; ATP1B; ATP1B1; ATPase Na+/K+ transporting subunit beta 1; ATPase, Na+/K+ transporting, beta 1 polypeptide; Beta 1-subunit of Na(+),K(+)-ATPase; MGC1798; Na, K-ATPase beta-1 polypeptide; Na,K-ATPase beta 1 subunit; sodium pump subunit beta-1; sodium-potassium ATPase subunit beta 1 (non-catalytic); sodium/potassium-dependent ATPase beta-1 subunit; Sodium/potassium-dependent ATPase subunit beta-1; sodium/potassium-transporting ATPase beta-1 chain; Sodium/potassium-transporting ATPase subunit beta-1
Gene Symbols: ATP1B1
Molecular weight: 35,061 Da
Basal Isoelectric point: 8.74  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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ATP1B1

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene