PPAP2A Broad-specificity phosphohydrolase that dephosphorylates exogenous bioactive glycerolipids and sphingolipids. Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). Pivotal regulator of lysophosphatidic acid (LPA) signaling in the cardiovascular system. Major enzyme responsible of dephosphorylating LPA in platelets, which terminates signaling actions of LPA. May control circulating, and possibly also regulate localized, LPA levels resulting from platelet activation. It has little activity towards ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P). The relative catalytic efficiency is LPA Belongs to the PA-phosphatase related phosphoesterase family. Ubiquitously expressed with highest expression found in prostate. Isoform 1 is predominant in kidney, lung, placenta and liver. Isoform 2 is predominant in heart and pancreas. Found to be down-regulated in colon adenocarcinomas. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerolipid; Lipid Metabolism - glycerophospholipid; Lipid Metabolism - sphingolipid; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Phosphatase (non-protein)
Chromosomal Location of Human Ortholog: 5q11.2
Cellular Component:  integral component of plasma membrane; membrane; plasma membrane
Molecular Function:  lipid phosphatase activity; phosphatidate phosphatase activity; sphingosine-1-phosphate phosphatase activity
Biological Process:  androgen receptor signaling pathway; germ cell migration; intracellular steroid hormone receptor signaling pathway; lipid metabolic process; negative regulation of cell proliferation; phospholipid dephosphorylation; protein dephosphorylation; protein kinase C-activating G protein-coupled receptor signaling pathway; regulation of lipid metabolic process; sphingolipid biosynthetic process
Reference #:  O14494 (UniProtKB)
Alt. Names/Synonyms: Lipid phosphate phosphohydrolase 1; lipid phosphate phosphohydrolase 1a; LLP1a; LPP1; PAP-2a; PAP2; PAP2-alpha; PAP2a; PAP2a2; PAP2alpha2; PAPalpha1; Phosphatidate phosphohydrolase type 2a; Phosphatidic acid phosphatase 2a; phosphatidic acid phosphatase type 2A; phosphatidic acid phosphohydrolase type 2a; Phospholipid phosphatase 1; PPAP2A; type 2 phosphatidic acid phosphohydrolase; type-2 phosphatidic acid phosphatase alpha
Gene Symbols: PLPP1
Molecular weight: 32,156 Da
Basal Isoelectric point: 8.1  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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