ALDH1A3 NAD-dependent aldehyde dehydrogenase that catalyzes the formation of retinoic acid. Has high activity with all-trans retinal, and has much lower in vitro activity with acetaldehyde. Required for the biosynthesis of normal levels of retinoic acid in the embryonic ocular and nasal regions; retinoic acid is required for normal embryonic development of the eye and the nasal region. Belongs to the aldehyde dehydrogenase family. Expressed at low levels in many tissues and at higher levels in salivary gland, stomach, and kidney. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - histidine; Amino Acid Metabolism - phenylalanine; Amino Acid Metabolism - tyrosine; Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC; Oxidoreductase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Xenobiotic Metabolism - metabolism by cytochrome P450
Chromosomal Location of Human Ortholog: 15q26.3
Cellular Component:  cytoplasm; cytosol; nucleus; plasma membrane
Molecular Function:  aldehyde dehydrogenase [NAD(P)+] activity; NAD+ binding; protein homodimerization activity; retinal dehydrogenase activity; thyroid hormone binding
Biological Process:  embryonic camera-type eye development; embryonic eye morphogenesis; face development; Harderian gland development; inner ear morphogenesis; locomotory behavior; neuromuscular process controlling balance; nucleus accumbens development; olfactory pit development; optic cup morphogenesis involved in camera-type eye development; oxidation-reduction process; positive regulation of apoptotic process; protein homotetramerization; retinal metabolic process; retinoic acid biosynthetic process; retinoic acid metabolic process; retinol metabolic process; righting reflex
Disease: Microphthalmia, Isolated 8
Reference #:  P47895 (UniProtKB)
Alt. Names/Synonyms: acetaldehyde dehydrogenase 6; AL1A3; aldehyde dehydrogenase 1 family member A3; aldehyde dehydrogenase 1 family, member A3; Aldehyde dehydrogenase 6; Aldehyde dehydrogenase family 1 member A3; ALDH1A3; ALDH1A6; ALDH6; MCOP8; RALDH-3; RalDH3; Retinaldehyde dehydrogenase 3
Gene Symbols: ALDH1A3
Molecular weight: 56,108 Da
Basal Isoelectric point: 6.99  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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