ARRDC3
an arrestin protein that plays a role in regulating cell-surface expression of adrenergic receptors and probably also other G protein-coupled receptors. Plays a role in NEDD4-mediated ubiquitination and endocytosis af activated ADRB2 and subsequent ADRB2 degradation. May recruit NEDD4 to ADRB2. Alternatively, may function as adapter protein that does not play a major role in recruiting NEDD4 to ADRB2, but rather plays a role in a targeting ADRB2 to endosomes. Belongs to the arrestin family. Highly expressed in skeletal muscle, placenta, kidney, lung, liver, blood, adrenal gland, lymph node, mammary gland, thyroid, and trachea. Very low levels in colon, thymus, spleen, small intestine, bladder and bone marrow. Strong expression in differentiated adipocytes compared to preadipocytes. Detected in omental fat and subcutaneous fat tissue. Note: This description may include information from UniProtKB.
Cellular Component: cytoplasm; early endosome; endosome; lysosome; plasma membrane
Molecular Function: beta-3 adrenergic receptor binding; protein binding
Biological Process: fat pad development; heat generation; negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway; negative regulation of cold-induced thermogenesis; negative regulation of heat generation; negative regulation of locomotion involved in locomotory behavior; positive regulation of hippo signaling; positive regulation of ubiquitin-protein transferase activity; protein transport; skin development