PARPBP
Required to suppress inappropriate homologous recombination, thereby playing a central role DNA repair and in the maintenance of genomic stability. Antagonizes homologous recombination by interfering with the formation of the RAD51-DNA homologous recombination structure. Binds single-strand DNA and poly(A) homopolymers. Positively regulate the poly(ADP-ribosyl)ation activity of PARP1; however such function may be indirect. Belongs to the PARI family. Restricted to testis. Overexpressed in multiple cancer cells. 7 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Unknown function |
Chromosomal Location of human Ortholog: 12q23.2 |
Cellular Component:
chromatin; cytoplasm; nucleoplasm
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Molecular Function:
DNA binding; protein binding
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Biological Process:
DNA repair; negative regulation of double-strand break repair via homologous recombination
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Reference #:
Q9NWS1
(UniProtKB)
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Alt. Names/Synonyms: AROM; C12orf48; chromosome 12 open reading frame 48; CL048; FLJ20641; hypothetical protein LOC55010; PARI; PARP-1 binding protein; PARP1 binding protein; PARP1-binding protein; PARPBP; PCNA-interacting partner; UPF0419 protein C12orf48
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Gene Symbols: PARPBP
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Molecular weight:
65,054 Da
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Basal Isoelectric point:
8.96
Predict pI for various phosphorylation states
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