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MCA32
Immunoglobulin-like receptor which plays an inhibitory role in degranulation of mast cells. Negatively regulates IgE-mediated mast cell activation and suppresses the type I immediate hypersensitivity reaction. Expressed in myeloid cells (dendritic cells, macrophages and neutrophils, weak expression on B-cells but not in T-cells or natural killer cells), peripheral blood basophils and mast cells (at protein level). 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Membrane protein, integral |
| Chromosomal Location of human Ortholog: 17q23.3 |
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Cellular Component:
plasma membrane
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Molecular Function:
protein binding; transmembrane signaling receptor activity
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Biological Process:
cell surface receptor signaling pathway; mast cell degranulation; negative regulation of mast cell activation
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Reference #:
Q7Z6M3
(UniProtKB)
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Alt. Names/Synonyms: Allergin-1; Allergy inhibitory receptor 1; C17orf60; chromosome 17 open reading frame 60; Mast cell antigen 32; mast cell immunoglobulin like receptor 1; Mast cell immunoglobulin-like receptor 1; MCA-32; MCA32; MGC163278; MILR1; Probable mast cell antigen 32 homolog
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Gene Symbols: MILR1
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Molecular weight:
38,735 Da
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Basal Isoelectric point:
7.91
Predict pI for various phosphorylation states
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