MPP7 Acts as an important adapter that promotes epithelial cell polarity and tight junction formation via its interaction with DLG1. Involved in the assembly of protein complexes at sites of cell-cell contact. Belongs to the MAGUK family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of human Ortholog: 10p12.1
Cellular Component:  adherens junction; bicellular tight junction; cell cortex; cell junction; cell-cell junction; lateral plasma membrane; MPP7-DLG1-LIN7 complex; nucleoplasm; plasma membrane
Molecular Function:  molecular adaptor activity; protein binding; protein domain specific binding; signaling adaptor activity
Biological Process:  bicellular tight junction assembly; establishment of cell polarity; positive regulation of protein-containing complex assembly; protein localization to adherens junction
Reference #:  Q5T2T1 (UniProtKB)
Alt. Names/Synonyms: FLJ32798; MAGUK p55 subfamily member 7; membrane palmitoylated protein 7; membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7); MPP7
Gene Symbols: MPP7
Molecular weight: 65,524 Da
Basal Isoelectric point: 6.65  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein