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MPP7
Acts as an important adapter that promotes epithelial cell polarity and tight junction formation via its interaction with DLG1. Involved in the assembly of protein complexes at sites of cell-cell contact. Belongs to the MAGUK family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold |
| Chromosomal Location of human Ortholog: 10p12.1 |
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Cellular Component:
adherens junction; bicellular tight junction; cell cortex; cell junction; cell-cell junction; lateral plasma membrane; MPP7-DLG1-LIN7 complex; nucleoplasm; plasma membrane
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Molecular Function:
molecular adaptor activity; protein binding; protein domain specific binding; signaling adaptor activity
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Biological Process:
bicellular tight junction assembly; establishment of cell polarity; positive regulation of protein-containing complex assembly; protein localization to adherens junction
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Reference #:
Q5T2T1
(UniProtKB)
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Alt. Names/Synonyms: FLJ32798; MAGUK p55 subfamily member 7; membrane palmitoylated protein 7; membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7); MPP7
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Gene Symbols: MPP7
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Molecular weight:
65,524 Da
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Basal Isoelectric point:
6.65
Predict pI for various phosphorylation states
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