JADE1 Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Transcriptional coactivator, it may also promote acetylation of nucleosomal histone H4 by KAT5. Promotes apoptosis. May act as a renal tumor suppressor. Negatively regulates canonical Wnt signaling; at least in part, cooperates with NPHP4 in this function. Belongs to the JADE family. Highly expressed in kidney. Also present in pancreas, liver and heart (at protein level). Down-regulated in renal cancer cells. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Tumor suppressor
Chromosomal Location of Human Ortholog: 4q28.2
Cellular Component:  ciliary basal body; cytoplasm; histone acetyltransferase complex; nuclear speck; nucleoplasm; nucleus; plasma membrane
Molecular Function:  metal ion binding; protein binding; transcription coactivator activity
Biological Process:  apoptotic process; histone H3 acetylation; histone H4-K12 acetylation; histone H4-K5 acetylation; histone H4-K8 acetylation; negative regulation of canonical Wnt signaling pathway; negative regulation of cell growth; negative regulation of G1/S transition of mitotic cell cycle; positive regulation of nucleic acid-templated transcription
Reference #:  Q6IE81 (UniProtKB)
Alt. Names/Synonyms: FLJ22479; gene for apoptosis and differentiation in epithelia; jade family PHD finger 1; Jade family PHD finger protein 1; JADE1; KIAA1807; PHD finger protein 17; PHD protein Jade-1; PHF17; Protein Jade-1
Gene Symbols: JADE1
Molecular weight: 95,533 Da
Basal Isoelectric point: 8.2  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein