HIRA Cooperates with ASF1A to promote replication-independent chromatin assembly. Required for the periodic repression of histone gene transcription during the cell cycle. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit. Belongs to the WD repeat HIR1 family. Expressed at high levels in kidney, pancreas and skeletal muscle and at lower levels in brain, heart, liver, lung, and placenta. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; Cell development/differentiation; Transcription regulation
Chromosomal Location of Human Ortholog: 22q11.21
Cellular Component:  chromosome, centromeric region; nuclear chromatin; nucleoplasm; nucleus; PML body; protein-containing complex
Molecular Function:  DNA-binding transcription factor activity; protein binding
Biological Process:  anatomical structure morphogenesis; DNA replication-independent nucleosome assembly; gastrulation; muscle cell differentiation; osteoblast differentiation; regulation of transcription by RNA polymerase II; transcription, DNA-templated
Reference #:  P54198 (UniProtKB)
Alt. Names/Synonyms: DGCR1; DiGeorge critical region gene 1; HIR; HIR histone cell cycle regulation defective homolog A (S. cerevisiae); HIRA; Protein HIRA; TUP1; TUP1-like enhancer of split protein 1; TUPLE1
Gene Symbols: HIRA
Molecular weight: 111,835 Da
Basal Isoelectric point: 8.4  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB