G-gamma 12 Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Belongs to the G protein gamma family. Note: This description may include information from UniProtKB.
Protein type: G protein; G protein, heterotrimeric; G protein, heterotrimeric gamma
Chromosomal Location of mouse Ortholog: 6 C1|6 30.68 cM
Cellular Component:  G-protein beta/gamma-subunit complex; heterotrimeric G-protein complex; membrane; plasma membrane
Molecular Function:  G-protein beta-subunit binding; GTPase activity; PDZ domain binding; phosphate ion binding
Biological Process:  G protein-coupled receptor signaling pathway; signal transduction
Reference #:  Q9DAS9 (UniProtKB)
Alt. Names/Synonyms: 2010305F15Rik; AA536815; AI115529; AI314170; AI842738; G-gamma 12; GBG12; Gng12; guanine nucleotide binding protein (G protein), gamma 12; Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12; OTTMUSP00000026466; OTTMUSP00000026467; OTTMUSP00000026468; OTTMUSP00000026469; OTTMUSP00000026470; OTTMUSP00000026471; OTTMUSP00000026472
Gene Symbols: Gng12
Molecular weight: 7,997 Da
Basal Isoelectric point: 9.14  Predict pI for various phosphorylation states
CST Pathways:  GPCR Signaling to MAPKs  |  Parkinson's Disease  |  Phospholipase Signaling  |  PI3K/Akt Signaling  |  SAPK/JNK Signaling Cascades
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G-gamma 12

Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene