Kv2.2 Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and smooth muscle cells. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient. Homotetrameric channels mediate a delayed-rectifier voltage-dependent outward potassium current that display rapid activation and slow inactivation in response to membrane depolarization. Can form functional homotetrameric and heterotetrameric channels that contain variable proportions of KCNB1; channel properties depend on the type of alpha subunits that are part of the channel. Can also form functional heterotetrameric channels with other alpha subunits that are non-conducting when expressed alone, such as KCNS1 and KCNS2, creating a functionally diverse range of channel complexes. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Contributes to the delayed-rectifier voltage-gated potassium current in cortical pyramidal neurons and smooth muscle cells. Belongs to the potassium channel family. B (Shab) (TC 1.A.1.2) subfamily. Kv2.2/KCNB2 sub-subfamily. Note: This description may include information from UniProtKB.
Protein type: Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 5q11
Cellular Component:  dendrite; integral component of membrane; neuronal cell body; neuronal cell body membrane; perikaryon; plasma membrane; voltage-gated potassium channel complex
Molecular Function:  delayed rectifier potassium channel activity; ion channel binding; protein heterodimerization activity; voltage-gated potassium channel activity
Biological Process:  potassium ion transmembrane transport; potassium ion transport; protein homooligomerization; protein localization to plasma membrane; regulation of ion transmembrane transport
Reference #:  Q63099 (UniProtKB)
Alt. Names/Synonyms: CDRK; Kcnb2; Kv2.2; potassium voltage gated channel, Shab-related subfamily, member 2; Potassium voltage-gated channel subfamily B member 2; Voltage-gated potassium channel subunit Kv2.2
Gene Symbols: Kcnb2
Molecular weight: 102,096 Da
Basal Isoelectric point: 5.75  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  UniProtKB  |  Entrez-Gene  |  GenPept