SLC35D2 Antiporter transporting nucleotide sugars such as UDP-N-acetylglucosamine (UDP-GlcNAc), UDP-glucose (UDP-Glc) and GDP-mannose (GDP-Man) pooled in the cytosol into the lumen of the Golgi in exchange for the corresponding nucleosides monophosphates (UMP for UDP-sugars and GMP for GDP-sugars). May take part in heparan sulfate synthesis by supplying UDP-Glc-NAc, the donor substrate, and thus be involved in growth factor signaling. Belongs to the TPT transporter family. SLC35D subfamily. Highly expressed in heart, kidney, small intestine, placenta, lung and peripheral blood leukocyte. Weakly expressed in skeletal muscle and spleen. Not expressed in brain, colon and thymus. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family
Chromosomal Location of Human Ortholog: 9q22.32
Cellular Component:  Golgi apparatus; Golgi membrane; integral component of membrane
Molecular Function:  nucleotide-sugar transmembrane transporter activity
Biological Process:  carbohydrate transport; glycosaminoglycan biosynthetic process; keratan sulfate biosynthetic process; UDP-glucuronic acid transmembrane transport; UDP-N-acetylgalactosamine transmembrane transport; UDP-N-acetylglucosamine transmembrane transport
Reference #:  Q76EJ3 (UniProtKB)
Alt. Names/Synonyms: fringe connection; HFRC; HFRC1; Homolog of Fringe connection protein 1; MGC117215; MGC142139; S35D2; SLC35D2; solute carrier family 35 (UDP-GlcNAc/UDP-glucose transporter), member D2; Solute carrier family 35 member D2; solute carrier family 35, member D2; SQV7-like protein; SQV7L; UDP-galactose transporter-related protein 8; UDP-N-acetylglucosamine transporter; UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter; UGTREL8
Gene Symbols: SLC35D2
Molecular weight: 36,673 Da
Basal Isoelectric point: 8.89  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene