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SLC35D2
Antiporter transporting nucleotide sugars such as UDP-N-acetylglucosamine (UDP-GlcNAc), UDP-glucose (UDP-Glc) and GDP-mannose (GDP-Man) pooled in the cytosol into the lumen of the Golgi in exchange for the corresponding nucleosides monophosphates (UMP for UDP-sugars and GMP for GDP-sugars). May take part in heparan sulfate synthesis by supplying UDP-Glc-NAc, the donor substrate, and thus be involved in growth factor signaling. Belongs to the TPT transporter family. SLC35D subfamily. Highly expressed in heart, kidney, small intestine, placenta, lung and peripheral blood leukocyte. Weakly expressed in skeletal muscle and spleen. Not expressed in brain, colon and thymus. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family |
| Chromosomal Location of human Ortholog: 9q22.32 |
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Cellular Component:
Golgi apparatus; Golgi membrane
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Molecular Function:
antiporter activity; GDP-fucose transmembrane transporter activity; nucleotide-sugar transmembrane transporter activity; UDP-glucuronic acid transmembrane transporter activity; UDP-N-acetylgalactosamine transmembrane transporter activity; UDP-N-acetylglucosamine transmembrane transporter activity
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Biological Process:
carbohydrate transport; GDP-fucose transmembrane transport; heparan sulfate proteoglycan biosynthetic process; keratan sulfate biosynthetic process; UDP-glucuronic acid transmembrane transport; UDP-N-acetylgalactosamine transmembrane transport; UDP-N-acetylglucosamine transmembrane transport
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Reference #:
Q76EJ3
(UniProtKB)
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Alt. Names/Synonyms: fringe connection; HFRC; HFRC1; Homolog of Fringe connection protein 1; MGC117215; MGC142139; Nucleotide sugar transporter SLC35D2; S35D2; SLC35D2; solute carrier family 35 (UDP-GlcNAc/UDP-glucose transporter), member D2; Solute carrier family 35 member D2; solute carrier family 35, member D2; SQV7-like protein; SQV7L; UDP-galactose transporter-related protein 8; UDP-N-acetylglucosamine transporter; UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter; UGTREL8
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Gene Symbols: SLC35D2
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Molecular weight:
36,673 Da
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Basal Isoelectric point:
8.89
Predict pI for various phosphorylation states
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