TPCN1 Nicotinic acid adenine dinucleotide phosphate (NAADP) receptor that may function as one of the major voltage-gated Ca(2+) channels (VDCC) across the lysosomal and endosomal membrane. Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. Two pore calcium channel subfamily. Highest expression found in the heart and kidney, and lowest expression found in the spleen. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel
Chromosomal Location of mouse Ortholog: 5|5 F
Cellular Component:  endosome; endosome membrane; integral component of membrane; lysosomal membrane; lysosome; membrane
Molecular Function:  calcium channel activity; identical protein binding; ion channel activity; NAADP-sensitive calcium-release channel activity; voltage-gated calcium channel activity; voltage-gated ion channel activity
Biological Process:  calcium ion transmembrane transport; calcium ion transport; ion transport; positive regulation of autophagy; regulation of ion transmembrane transport; transmembrane transport
Reference #:  Q9EQJ0 (UniProtKB)
Alt. Names/Synonyms: 5730403B01Rik; Kiaa1169; mKIAA1169; Tpc1; Tpcn1; Two pore calcium channel protein 1; two pore channel 1; Voltage-dependent calcium channel protein TPC1
Gene Symbols: Tpcn1
Molecular weight: 94,496 Da
Basal Isoelectric point: 8.7  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene