TPCN1
Nicotinic acid adenine dinucleotide phosphate (NAADP) receptor that may function as one of the major voltage-gated Ca(2+) channels (VDCC) across the lysosomal and endosomal membrane. Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. Two pore calcium channel subfamily. Highest expression found in the heart and kidney, and lowest expression found in the spleen. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel |
Chromosomal Location of human Ortholog: 12q24.13 |
Cellular Component:
early endosome membrane; endolysosome; endosome; endosome membrane; lysosomal membrane; lysosome; recycling endosome membrane
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Molecular Function:
identical protein binding; intracellular phosphatidylinositol-3,5-bisphosphate-sensitive monatomic cation channel activity; ligand-gated sodium channel activity; NAADP-sensitive calcium-release channel activity; phosphatidylinositol-3,5-bisphosphate binding; protein binding; protein homodimerization activity; syntaxin binding; voltage-gated monoatomic ion channel activity; voltage-gated sodium channel activity
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Biological Process:
endocytosis involved in viral entry into host cell; monoatomic ion transmembrane transport; positive regulation of autophagy; regulation of monoatomic ion transmembrane transport; release of sequestered calcium ion into cytosol; sodium ion transmembrane transport
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Reference #:
Q9ULQ1
(UniProtKB)
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Alt. Names/Synonyms: FLJ20612; KIAA1169; TPC1; TPCN1; Two pore calcium channel protein 1; Two pore channel protein 1; two pore segment channel 1; two-pore channel 1; two-pore channel 1, homolog; two-pore segment channel 1; Voltage-dependent calcium channel protein TPC1
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Gene Symbols: TPCN1
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Molecular weight:
94,147 Da
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Basal Isoelectric point:
8.47
Predict pI for various phosphorylation states
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