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LACE1
Putative mitochondrial ATPase. Plays a role in mitochondrial morphology and mitochondrial protein metabolism. Promotes degradation of excess nuclear-encoded complex IV subunits (COX4I1, COX5A and COX6A1) and normal activity of complexes III and IV of the respiratory chain. Mediates mitochondrial translocation of TP53 and its transcription-independent apoptosis in response to genotoxic stress. Belongs to the AFG1 ATPase family. Note: This description may include information from UniProtKB.
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| Protein type: Unknown function |
| Chromosomal Location of Human Ortholog: 6q21 |
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Cellular Component:
mitochondrial membrane; mitochondrion
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Molecular Function:
ATP binding; protein binding
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Biological Process:
mitochondrial electron transport, cytochrome c to oxygen; mitochondrial protein catabolic process; mitochondrion organization
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Reference #:
Q8WV93
(UniProtKB)
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Alt. Names/Synonyms: AFG1; AFG1 like ATPase; AFG1-like ATPase; AFG1L; ATPase family gene 1 homolog; c222389; CG8520 gene product; LACE1; lactation elevated 1; Lactation elevated protein 1; Protein AFG1 homolog
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Gene Symbols: AFG1L
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Molecular weight:
54,845 Da
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Basal Isoelectric point:
6.87
Predict pI for various phosphorylation states
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