LACE1 Putative mitochondrial ATPase. Plays a role in mitochondrial morphology and mitochondrial protein metabolism. Promotes degradation of excess nuclear-encoded complex IV subunits (COX4I1, COX5A and COX6A1) and normal activity of complexes III and IV of the respiratory chain. Mediates mitochondrial translocation of TP53 and its transcription-independent apoptosis in response to genotoxic stress. Belongs to the AFG1 ATPase family. Note: This description may include information from UniProtKB.
Protein type: Unknown function
Chromosomal Location of Human Ortholog: 6q21
Cellular Component:  mitochondrial membrane; mitochondrion
Molecular Function:  ATP binding; protein binding
Biological Process:  mitochondrial electron transport, cytochrome c to oxygen; mitochondrial protein catabolic process; mitochondrion organization
Reference #:  Q8WV93 (UniProtKB)
Alt. Names/Synonyms: AFG1; AFG1 like ATPase; AFG1-like ATPase; AFG1L; ATPase family gene 1 homolog; c222389; CG8520 gene product; LACE1; lactation elevated 1; Lactation elevated protein 1; Protein AFG1 homolog
Gene Symbols: AFG1L
Molecular weight: 54,845 Da
Basal Isoelectric point: 6.87  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene