Jun Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) cells. Binds to the USP28 promoter in colorectal cancer (CRC) cells. Belongs to the bZIP family. Jun subfamily. Note: This description may include information from UniProtKB.
Protein type: Oncoprotein; Transcription factor
Chromosomal Location of Human Ortholog: 5q33
Cellular Component:  cytosol; nuclear chromatin; nuclear euchromatin; nucleoplasm; nucleus; transcription factor AP-1 complex; transcription factor complex; transcriptional repressor complex
Molecular Function:  activating transcription factor binding; cAMP response element binding; chromatin binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; double-stranded DNA binding; enzyme binding; GTPase activator activity; HMG box domain binding; identical protein binding; protein binding; protein heterodimerization activity; protein homodimerization activity; R-SMAD binding; RNA polymerase II activating transcription factor binding; RNA polymerase II distal enhancer sequence-specific DNA binding; RNA polymerase II proximal promoter sequence-specific DNA binding; sequence-specific DNA binding; transcription coactivator activity; transcription factor binding; transcription regulatory region DNA binding; transcription regulatory region sequence-specific DNA binding; ubiquitin protein ligase binding; ubiquitin-like protein ligase binding
Biological Process:  aging; angiogenesis; axon regeneration; cellular process; cellular response to cadmium ion; cellular response to calcium ion; cellular response to hormone stimulus; cellular response to lipopolysaccharide; cellular response to potassium ion starvation; cellular response to reactive oxygen species; circadian rhythm; eyelid development in camera-type eye; immune response; leading edge cell differentiation; learning; liver development; membrane depolarization; microglial cell activation; monocyte differentiation; negative regulation by host of viral transcription; negative regulation of apoptotic process; negative regulation of cell proliferation; negative regulation of DNA binding; negative regulation of neuron apoptotic process; negative regulation of protein autophosphorylation; negative regulation of transcription by RNA polymerase II; negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress; negative regulation of transcription, DNA-templated; outflow tract morphogenesis; positive regulation by host of viral transcription; positive regulation of apoptotic process; positive regulation of cell differentiation; positive regulation of cell proliferation; positive regulation of DNA replication; positive regulation of DNA-binding transcription factor activity; positive regulation of DNA-templated transcription, initiation; positive regulation of endothelial cell proliferation; positive regulation of epithelial cell migration; positive regulation of ERK1 and ERK2 cascade; positive regulation of fibroblast proliferation; positive regulation of GTPase activity; positive regulation of monocyte differentiation; positive regulation of neuron apoptotic process; positive regulation of pri-miRNA transcription by RNA polymerase II; positive regulation of smooth muscle cell proliferation; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; positive regulation of vascular smooth muscle cell proliferation; Ras protein signal transduction; regulation of cell cycle; regulation of transcription, DNA-templated; release of cytochrome c from mitochondria; response to cAMP; response to cytokine; response to drug; response to hydrogen peroxide; response to lipopolysaccharide; response to mechanical stimulus; response to muscle stretch; response to organic cyclic compound; response to organic substance; response to radiation; SMAD protein signal transduction; transcription by RNA polymerase II; transcription, DNA-templated; transforming growth factor beta receptor signaling pathway
Reference #:  P17325 (UniProtKB)
Alt. Names/Synonyms: Activator protein 1; AP1; Avian sarcoma virus 17 (v-jun) oncogene homolog; Jun; Jun oncogene; Proto-oncogene c-Jun; Rjg-9; Transcription factor AP-1; V-jun avian sarcoma virus 17 oncogene homolog; v-jun sarcoma virus 17 oncogene homolog
Gene Symbols: Jun
Molecular weight: 36,001 Da
Basal Isoelectric point: 8.88  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  SAPK/JNK Signaling Cascades  |  T Cell Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Jun

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene