|
Jun
Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) cells. Binds to the USP28 promoter in colorectal cancer (CRC) cells. Belongs to the bZIP family. Jun subfamily. Note: This description may include information from UniProtKB.
|
| Protein type: Oncoprotein; Transcription factor |
| Chromosomal Location of rat Ortholog: 5q33 |
|
Cellular Component:
chromatin; euchromatin; nucleoplasm; nucleus; protein-containing complex; RNA polymerase II transcription regulator complex; transcription factor AP-1 complex; transcription regulator complex; transcription repressor complex
|
|
Molecular Function:
cAMP response element binding; chromatin binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; double-stranded DNA binding; enzyme binding; general transcription initiation factor binding; GTPase activator activity; HMG box domain binding; identical protein binding; protein binding; protein homodimerization activity; protein-containing complex binding; R-SMAD binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; sequence-specific DNA binding; sequence-specific double-stranded DNA binding; transcription cis-regulatory region binding; transcription factor binding; ubiquitin protein ligase binding; ubiquitin-like protein ligase binding
|
|
Biological Process:
angiogenesis; apoptotic process; axon regeneration; cell population proliferation; cellular response to anisomycin; cellular response to cadmium ion; cellular response to calcium ion; cellular response to hypoxia; cellular response to lipopolysaccharide; cellular response to potassium ion starvation; cellular response to prolactin; cellular response to reactive oxygen species; cellular response to zinc ion starvation; circadian rhythm; DNA-templated transcription; eyelid development in camera-type eye; immune response; leading edge cell differentiation; learning; liver development; membrane depolarization; microglial cell activation; monocyte differentiation; negative regulation of apoptotic process; negative regulation of cell population proliferation; negative regulation of DNA binding; negative regulation of DNA-templated transcription; negative regulation of neuron apoptotic process; negative regulation of protein autophosphorylation; negative regulation of transcription by RNA polymerase II; negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress; outflow tract morphogenesis; positive regulation of apoptotic process; positive regulation of cell population proliferation; positive regulation of DNA replication; positive regulation of DNA-binding transcription factor activity; positive regulation of DNA-templated transcription; positive regulation of DNA-templated transcription initiation; positive regulation of endothelial cell proliferation; positive regulation of epithelial cell migration; positive regulation of ERK1 and ERK2 cascade; positive regulation of fibroblast proliferation; positive regulation of miRNA transcription; positive regulation of monocyte differentiation; positive regulation of neuron apoptotic process; positive regulation of smooth muscle cell proliferation; positive regulation of transcription by RNA polymerase II; positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus; positive regulation of vascular associated smooth muscle cell proliferation; regulation of cell cycle; regulation of cell population proliferation; regulation of DNA-templated transcription; regulation of transcription by RNA polymerase II; release from viral latency; release of cytochrome c from mitochondria; response to cAMP; response to cytokine; response to ethanol; response to hydrogen peroxide; response to insulin; response to lipopolysaccharide; response to mechanical stimulus; response to muscle stretch; response to organic cyclic compound; response to organic substance; response to steroid hormone; response to xenobiotic stimulus; SMAD protein signal transduction; transcription by RNA polymerase II; transforming growth factor beta receptor signaling pathway
|
|
Reference #:
P17325
(UniProtKB)
|
|
Alt. Names/Synonyms: Activator protein 1; AP1; Avian sarcoma virus 17 (v-jun) oncogene homolog; Jun; Jun oncogene; Proto-oncogene c-Jun; Rjg-9; Transcription factor AP-1; Transcription factor Jun; V-jun avian sarcoma virus 17 oncogene homolog; v-jun sarcoma virus 17 oncogene homolog
|
|
Gene Symbols: Jun
|
|
Molecular weight:
36,001 Da
|
|
Basal Isoelectric point:
8.88
Predict pI for various phosphorylation states
|
|
CST Pathways:
Apoptosis Regulation
|
B Cell Receptor Signaling
|
ErbB/HER Signaling
|
SAPK/JNK Signaling Cascades
|
T Cell Receptor Signaling
|
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
|
