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KRas
Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the regulation of cell proliferation. Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304-dependent manner. Belongs to the small GTPase superfamily. Ras family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: G protein; G protein, monomeric; G protein, monomeric, Ras; Motility/polarity/chemotaxis; Oncoprotein |
| Chromosomal Location of human Ortholog: 12p12.1 |
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Cellular Component:
cytoplasm; cytoplasmic side of plasma membrane; cytosol; endoplasmic reticulum membrane; Golgi membrane; mitochondrial outer membrane; plasma membrane
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Molecular Function:
G protein activity; GDP binding; GTP binding; GTPase activity; protein binding; protein-containing complex binding; protein-membrane adaptor activity
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Biological Process:
actin cytoskeleton organization; endocrine signaling; epithelial tube branching involved in lung morphogenesis; forebrain astrocyte development; glial cell proliferation; homeostasis of number of cells within a tissue; MAPK cascade; negative regulation of epithelial cell differentiation; negative regulation of neuron apoptotic process; neuron apoptotic process; positive regulation of gene expression; positive regulation of glial cell proliferation; positive regulation of protein phosphorylation; positive regulation of Rac protein signal transduction; Rac protein signal transduction; Ras protein signal transduction; regulation of long-term neuronal synaptic plasticity; regulation of synaptic transmission, GABAergic; skeletal muscle cell differentiation; striated muscle cell differentiation; type I pneumocyte differentiation; visual learning
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Disease: Arteriovenous Malformations Of The Brain; Bladder Cancer; Breast Cancer; Cardiofaciocutaneous Syndrome 2; Gastric Cancer; Leukemia, Acute Myeloid; Lung Cancer; Noonan Syndrome 3; Oculoectodermal Syndrome; Ras-associated Autoimmune Leukoproliferative Disorder; Schimmelpenning-feuerstein-mims Syndrome
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Reference #:
P01116
(UniProtKB)
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Alt. Names/Synonyms: 'C-K-RAS; c-K-ras; c-Ki-ras; c-Ki-ras2; c-Kirsten-ras protein; cellular c-Ki-ras2 proto-oncogene; cellular transforming proto-oncogene; CFC2; GTPase KRas; GTPase KRas, N-terminally processed; K-Ras; K-Ras 2; K-ras p21 protein; K-RAS2A; K-RAS2B; K-RAS4A; K-RAS4B; Ki-Ras; Kirsten rat sarcoma viral oncogene homolog; Kirsten rat sarcoma viral proto-oncogene; Kirsten rat sarcoma-2 viral (v-Ki-ras2) oncogene homolog; KRAS; KRAS proto-oncogene, GTPase; KRAS1; KRAS2; NS; NS3; OES; oncogene KRAS2; PR310 c-K-ras oncogene; RALD; RASK; RASK2; transforming protein p21; v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog; v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
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Gene Symbols: KRAS
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Molecular weight:
21,656 Da
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Basal Isoelectric point:
6.33
Predict pI for various phosphorylation states
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CST Pathways:
Actin Dynamics
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Angiogenesis
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B Cell Receptor Signaling
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ErbB/HER Signaling
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ESC Pluripotency and Differentiation
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GPCR Signaling to MAPKs
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Growth And Differentiation Control by MAPKs
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IL6 Signaling
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Inhibition of Apoptosis
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Insulin Receptor Signaling
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NF-kB Signaling
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SAPK/JNK Signaling Cascades
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T Cell Receptor Signaling
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TGF-ß Signaling
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Warburg Effect
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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