ODZ1
Involved in neural development, regulating the establishment of proper connectivity within the nervous system. May function as a cellular signal transducer. Teneurin C-terminal-associated peptide: Plays a role in the regulation of neuroplasticity in the limbic system. Mediates a rapid reorganization of actin- and tubulin-based cytoskeleton elements with an increase in dendritic arborization and spine density formation of neurons in the hippocampus and amygdala. Induces BDNF transcription inhibition in neurons. Activates the mitogen-activated protein (MAP) kinase 2 (MEK2) and extracellular signal-regulated kinase (ERK) cascade. Acts also as a bioactive neuroprotective peptide on limbic neurons of the brain and regulates stress-induced behavior: attenuates alkalosis-associated necrotic cell death and the effects of corticotropin-releasing factor (CRF) on c-fos/FOS induction and on the reinstatement of cocaine seeking. Ten-1 intracellular domain: Induces gene transcription activation. Belongs to the tenascin family. Teneurin subfamily. Expressed in fetal brain. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Membrane protein, integral |
Chromosomal Location of mouse Ortholog: X|X A4 |
Cellular Component:
cytoplasm; cytoskeleton; extracellular region; membrane; neuron projection; nucleus; perinuclear region of cytoplasm; plasma membrane
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Molecular Function:
cell adhesion molecule binding; identical protein binding; protein binding; protein heterodimerization activity; protein homodimerization activity
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Biological Process:
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; neuron development; neuropeptide signaling pathway; positive regulation of actin filament polymerization; positive regulation of filopodium assembly; positive regulation of MAP kinase activity; positive regulation of peptidyl-serine phosphorylation; regulation of transcription by RNA polymerase III; signal transduction
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Reference #:
Q9WTS4
(UniProtKB)
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Alt. Names/Synonyms: IDten-1; odd Oz/ten-m homolog 1 (Drosophila); Odz; Odz1; Odz2; OTTMUSP00000018946; Protein Odd Oz/ten-m homolog 1; TCAP; TCAP-1; TCPA-1; Ten-1; Ten-1 ECD; Ten-1 extracellular domain; Ten-1 ICD; Ten-1 intracellular domain; Ten-m; Ten-m1; TEN1; Tenascin-M1; teneur; Teneurin C-terminal-associated peptide; Teneurin transmembrane protein 1; Teneurin-1; Tenm1; Tnm1
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Gene Symbols: Tenm1
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Molecular weight:
305,795 Da
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Basal Isoelectric point:
5.93
Predict pI for various phosphorylation states
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