TLCD1 Regulates the composition and fluidity of the plasma membrane. Inhibits the incorporation of membrane-fluidizing phospholipids containing omega-3 long-chain polyunsaturated fatty acids (LCPUFA) and thereby promotes membrane rigidity. Does not appear to have any effect on LCPUFA synthesis. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of human Ortholog: 17q11.2
Cellular Component:  integral component of membrane; plasma membrane
Biological Process:  membrane assembly; phospholipid homeostasis; plasma membrane organization; regulation of membrane lipid distribution
Reference #:  Q96CP7 (UniProtKB)
Alt. Names/Synonyms: Calfacilitin; LOC116238; TLC domain containing 1; TLC domain-containing protein 1; TLCD1
Gene Symbols: TLCD1
Molecular weight: 28,548 Da
Basal Isoelectric point: 9.54  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein