EWS
Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. Belongs to the RRM TET family. Ubiquitous. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Oncoprotein; RNA-binding; Transcription, coactivator/corepressor |
Chromosomal Location of human Ortholog: 22q12.2 |
Cellular Component:
Cajal body; cytoplasm; nucleolus; nucleoplasm; nucleus; plasma membrane
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Molecular Function:
calmodulin binding; identical protein binding; metal ion binding; protein binding; RNA binding; transcription coregulator activity
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Biological Process:
DNA-templated transcription; regulation of DNA-templated transcription
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Disease: Ewing Sarcoma
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Reference #:
Q01844
(UniProtKB)
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Alt. Names/Synonyms: bK984G1.4; Ewing sarcoma breakpoint region 1; Ewing sarcoma breakpoint region 1 protein; Ewings sarcoma EWS-Fli1 (type 1) oncogene; EWS; EWS oncogene; EWS RNA binding protein 1; EWS RNA-binding protein variant 6; EWS-FLI1; EWSR1; RNA-binding protein EWS
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Gene Symbols: EWSR1
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Molecular weight:
68,478 Da
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Basal Isoelectric point:
9.37
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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