EWS Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. Belongs to the RRM TET family. Ubiquitous. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Oncoprotein; RNA-binding; Transcription, coactivator/corepressor
Chromosomal Location of human Ortholog: 22q12.2
Cellular Component:  Cajal body; cytoplasm; nucleolus; nucleoplasm; nucleus; plasma membrane
Molecular Function:  calmodulin binding; identical protein binding; metal ion binding; protein binding; RNA binding; transcription coregulator activity
Biological Process:  DNA-templated transcription; regulation of DNA-templated transcription
Disease: Ewing Sarcoma
Reference #:  Q01844 (UniProtKB)
Alt. Names/Synonyms: bK984G1.4; Ewing sarcoma breakpoint region 1; Ewing sarcoma breakpoint region 1 protein; Ewings sarcoma EWS-Fli1 (type 1) oncogene; EWS; EWS oncogene; EWS RNA binding protein 1; EWS RNA-binding protein variant 6; EWS-FLI1; EWSR1; RNA-binding protein EWS
Gene Symbols: EWSR1
Molecular weight: 68,478 Da
Basal Isoelectric point: 9.37  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below

EWS

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein