EWS an oncogenic RNA-binding protein. Might normally function as a repressor. Binds RPB3, SF1, calmodulin and RNA. Interacts with and regulated by Pyk2. Relocates from cytoplasm to ribosomes upon Pyk2 activation. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. 5 alternatively-spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Oncoprotein; RNA-binding; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 22q12.2
Cellular Component:  cytoplasm; nucleolus; nucleus; plasma membrane
Molecular Function:  calmodulin binding; identical protein binding; metal ion binding; protein binding
Biological Process:  regulation of transcription, DNA-templated
Disease: Ewing Sarcoma
Reference #:  Q01844 (UniProtKB)
Alt. Names/Synonyms: bK984G1.4; Ewing sarcoma breakpoint region 1; Ewing sarcoma breakpoint region 1 protein; Ewings sarcoma EWS-Fli1 (type 1) oncogene; EWS; EWS oncogene; EWSR1; RNA-binding protein EWS
Gene Symbols: EWSR1
Molecular weight: 68,478 Da
Basal Isoelectric point: 9.37  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein