DAB1 Adapter molecule functioning in neural development. May regulate SIAH1 activity. Mainly expressed in brain. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of mouse Ortholog: 4 C6|4 47.79 cM
Cellular Component:  apical part of cell; brush border; cytoplasm; cytosol; intracellular membrane-bounded organelle; membrane; neuron projection; neuronal cell body; postsynaptic density
Molecular Function:  phosphatidylinositol 3-kinase binding; phospholipid binding; protein binding; SH2 domain binding
Biological Process:  adult walking behavior; cell differentiation; cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration; central nervous system development; cerebellum structural organization; cerebral cortex cell migration; cerebral cortex radially oriented cell migration; dendrite development; Golgi localization; hippocampus development; intracellular signal transduction; lateral motor column neuron migration; multicellular organism development; negative regulation of astrocyte differentiation; negative regulation of axonogenesis; negative regulation of cell adhesion; negative regulation of JAK-STAT cascade; nervous system development; neuron migration; positive regulation of neuron differentiation; positive regulation of protein kinase activity; radial glia guided migration of Purkinje cell; small GTPase mediated signal transduction; ventral spinal cord development
Reference #:  P97318 (UniProtKB)
Alt. Names/Synonyms: AI956902; C630028C02Rik; Dab1; disabled 1; Disabled homolog 1; disabled homolog 1 (Drosophila); OTTMUSP00000008462; RP23-356E21.1; scm; scr; scrambler; yot; yotari
Gene Symbols: Dab1
Molecular weight: 63,578 Da
Basal Isoelectric point: 4.88  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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DAB1

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene