DAB1 an adaptor molecule functioning in neural development. The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function. In mice, the disabled-1 gene plays a central role in brain development, directing the migration of cortical neurons past previously formed neurons to reach their proper layer. Thought to be a signal transducer that interacts with protein kinase pathways to regulate neuronal positioning in the developing brain. Associates with the SH2 domains of Src, Fyn and Abl. Phosphorylated in response to reelin induction in embryonic neurons Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 4 C6|4 47.79 cM
Cellular Component:  apical part of cell; brush border; cytoplasm; cytosol; intracellular membrane-bounded organelle; membrane; neuron projection; neuronal cell body; postsynaptic density
Molecular Function:  phosphatidylinositol 3-kinase binding; phospholipid binding; protein binding; SH2 domain binding
Biological Process:  adult walking behavior; cell differentiation; cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration; central nervous system development; cerebellum structural organization; cerebral cortex cell migration; cerebral cortex radially oriented cell migration; dendrite development; Golgi localization; hippocampus development; intracellular signal transduction; lateral motor column neuron migration; multicellular organism development; negative regulation of astrocyte differentiation; negative regulation of axonogenesis; negative regulation of cell adhesion; negative regulation of JAK-STAT cascade; nervous system development; neuron migration; positive regulation of neuron differentiation; positive regulation of protein kinase activity; radial glia guided migration of Purkinje cell; small GTPase mediated signal transduction; ventral spinal cord development
Reference #:  P97318 (UniProtKB)
Alt. Names/Synonyms: AI956902; C630028C02Rik; Dab1; Disabled homolog 1; disabled homolog 1 (Drosophila); OTTMUSP00000008462; RP23-356E21.1; scm; scr; scrambler; yot; yotari
Gene Symbols: Dab1
Molecular weight: 63,578 Da
Basal Isoelectric point: 4.88  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene