CRYAB May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. Belongs to the small heat shock protein (HSP20) family. Lens as well as other tissues (PubMed:838078, PubMed:2387586). Expressed in myocardial tissue (PubMed:28493373). Note: This description may include information from UniProtKB.
Protein type: Chaperone; Heat shock protein
Chromosomal Location of human Ortholog: 11q23.1
Cellular Component:  actin filament bundle; axon; cardiac myofibril; cell surface; cytoplasm; cytosol; dendritic spine; Golgi apparatus; M band; microtubule cytoskeleton; mitochondrion; nucleoplasm; nucleus; perikaryon; postsynaptic density; protein-containing complex; synaptic membrane; Z disc
Molecular Function:  amyloid-beta binding; identical protein binding; metal ion binding; microtubule binding; protein binding; protein homodimerization activity; protein-containing complex binding; structural constituent of eye lens; unfolded protein binding
Biological Process:  apoptotic process involved in morphogenesis; cellular response to gamma radiation; lens development in camera-type eye; microtubule polymerization or depolymerization; multicellular organism aging; muscle contraction; muscle organ development; negative regulation of amyloid fibril formation; negative regulation of apoptotic process; negative regulation of cell growth; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of intracellular transport; negative regulation of protein homooligomerization; negative regulation of reactive oxygen species metabolic process; negative regulation of transcription, DNA-templated; protein folding; protein homooligomerization; protein stabilization; regulation of cell death; regulation of cellular response to heat; response to estradiol; response to hydrogen peroxide; response to hypoxia; stress-activated MAPK cascade; tubulin complex assembly
Disease: Cardiomyopathy, Dilated, 1ii; Cataract 16, Multiple Types; Myopathy, Myofibrillar, 2; Myopathy, Myofibrillar, Fatal Infantile Hypertonic, Alpha-b Crystallin-related
Reference #:  P02511 (UniProtKB)
Alt. Names/Synonyms: alpha B crystallin; alpha crystallin B chain; Alpha(B)-crystallin; Alpha-crystallin B chain; CMD1II; CRYA2; CRYAB; crystallin alpha B; crystallin, alpha B; CTPP2; CTRCT16; epididymis secretory protein Li 101; Heat shock protein beta-5; heat-shock 20 kD like-protein; HEL-S-101; HspB5; MFM2; Renal carcinoma antigen NY-REN-27; Rosenthal fiber component
Gene Symbols: CRYAB
Molecular weight: 20,159 Da
Basal Isoelectric point: 6.76  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene