|
ADPRHL2
ADP-ribose glycohydrolase that preferentially hydrolyzes the scissile alpha-O-linkage attached to the anomeric C1'' position of ADP-ribose and acts on different substrates, such as proteins ADP-ribosylated on serine, free poly(ADP-ribose) and O-acetyl-ADP-D-ribose. Specifically acts as a serine mono-ADP-ribosylhydrolase by mediating the removal of mono-ADP-ribose attached to serine residues on proteins, thereby playing a key role in DNA damage response. Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage. Does not hydrolyze ADP-ribosyl-arginine, -cysteine, -diphthamide, or -asparagine bonds. Also able to degrade protein free poly(ADP-ribose), which is synthesized in response to DNA damage: free poly(ADP-ribose) acts as a potent cell death signal and its degradation by ADPRHL2 protects cells from poly(ADP-ribose)-dependent cell death, a process named parthanatos. Also hydrolyzes free poly(ADP-ribose) in mitochondria. Specifically digests O-acetyl-ADP-D-ribose, a product of deacetylation reactions catalyzed by sirtuins. Specifically degrades 1''-O-acetyl-ADP-D-ribose isomer, rather than 2''-O-acetyl-ADP-D-ribose or 3''-O-acetyl-ADP-D-ribose isomers. Belongs to the ADP-ribosylglycohydrolase family. Ubiquitous. Note: This description may include information from UniProtKB.
|
| Protein type: EC 3.2.1.143; Hydrolase |
| Chromosomal Location of mouse Ortholog: 4|4 D2.2 |
|
Cellular Component:
chromosome; cytoplasm; mitochondrion; nuclear body; nucleoplasm; nucleus; site of DNA damage
|
|
Molecular Function:
ADP-ribosylserine hydrolase activity; hydrolase activity; hydrolase activity, hydrolyzing O-glycosyl compounds; magnesium ion binding; metal ion binding; O-acetyl-ADP-ribose deacetylase activity; poly(ADP-ribose) glycohydrolase activity
|
|
Biological Process:
cellular response to superoxide; DNA damage response; DNA repair; negative regulation of necroptotic process; peptidyl-serine ADP-deribosylation
|
|
Reference #:
Q8CG72
(UniProtKB)
|
|
Alt. Names/Synonyms: [Protein ADP-ribosylarginine] hydrolase-like protein 2; [Protein ADP-ribosylserine] hydrolase; ADP-ribose glycohydrolase ARH3; ADP-ribosylhydrolase 2; ADP-ribosylhydrolase 3; ADP-ribosylhydrolase ARH3; ADP-ribosylhydrolase like 2; Adprhl2; ADPRS; AI836109; Arh3; ARHL2; ecto ADP-ribosylhydrolase; O-acetyl-ADP-ribose deacetylase ARH3; OTTMUSP00000009757; Poly(ADP-ribose) glycohydrolase ARH3
|
|
Gene Symbols: Adprs
|
|
Molecular weight:
39,414 Da
|
|
Basal Isoelectric point:
4.86
Predict pI for various phosphorylation states
|
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
|
