HEG1 Receptor component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity May act through the stabilization of endothelial cell junctions. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Calcium-binding; Membrane protein, integral
Chromosomal Location of Human Ortholog: 3q21.2
Cellular Component:  cell-cell junction; external side of plasma membrane; extracellular region; integral component of membrane
Molecular Function:  calcium ion binding; protein binding
Biological Process:  cardiac atrium morphogenesis; cardiac muscle tissue growth; cell-cell junction assembly; endothelial cell morphogenesis; in utero embryonic development; lung development; lymph circulation; lymph vessel development; multicellular organism growth; negative regulation of membrane permeability; negative regulation of Rho protein signal transduction; negative regulation of Rho-dependent protein serine/threonine kinase activity; pericardium development; positive regulation of fibroblast growth factor production; post-embryonic development; protein localization to cell junction; regulation of body fluid levels; vasculogenesis; venous blood vessel morphogenesis; ventricular septum development; ventricular trabecula myocardium morphogenesis
Reference #:  Q9ULI3 (UniProtKB)
Alt. Names/Synonyms: heart development protein with EGF like domains 1; heart of glass; HEG; HEG homolog 1 (zebrafish); HEG1; KIAA1237; MGC72175; MST112; MSTP112; Protein HEG homolog 1
Gene Symbols: HEG1
Molecular weight: 147,461 Da
Basal Isoelectric point: 5.8  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene