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ANXA1
Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing. Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors. Contributes to the adaptive immune response by enhancing signaling cascades that are triggered by T-cell activation, regulates differentiation and proliferation of activated T-cells. Promotes the differentiation of T-cells into Th1 cells and negatively regulates differentiation into Th2 cells. Has no effect on unstimulated T cells. Promotes rearrangement of the actin cytoskeleton, cell polarization and cell migration. Negatively regulates hormone exocytosis via activation of the formyl peptide receptors and reorganization of the actin cytoskeleton. Has high affinity for Ca(2+) and can bind up to eight Ca(2+) ions. Displays Ca(2+)-dependent binding to phospholipid membranes. Plays a role in the formation of phagocytic cups and phagosomes. Plays a role in phagocytosis by mediating the Ca(2+)-dependent interaction between phagosomes and the actin cytoskeleton. Belongs to the annexin family. Detected in resting neutrophils (PubMed:10772777). Detected in peripheral blood T-cells (PubMed:17008549). Detected in extracellular vesicles in blood serum from patients with inflammatory bowel disease, but not in serum from healthy donors (PubMed:25664854). Detected in placenta (at protein level) (PubMed:2532504). Detected in liver. Note: This description may include information from UniProtKB.
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| Protein type: Calcium-binding; Lipid-binding |
| Chromosomal Location of human Ortholog: 9q21.13 |
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Cellular Component:
actin filament; apical plasma membrane; basolateral plasma membrane; cell surface; cornified envelope; cytoplasm; cytosol; early endosome membrane; endosome; extracellular exosome; extracellular region; extracellular space; lateral plasma membrane; motile cilium; nucleoplasm; nucleus; phagocytic cup; plasma membrane; sarcolemma
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Molecular Function:
calcium ion binding; calcium-dependent phospholipid binding; calcium-dependent protein binding; lipid binding; phospholipase A2 inhibitor activity; phospholipid binding; protein binding; signaling receptor binding
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Biological Process:
actin cytoskeleton organization; adaptive immune response; alpha-beta T cell differentiation; arachidonic acid secretion; cell surface receptor signaling pathway; cell-cell adhesion; cellular response to glucocorticoid stimulus; cellular response to hydrogen peroxide; cellular response to vascular endothelial growth factor stimulus; DNA duplex unwinding; endocrine pancreas development; estrous cycle; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; gliogenesis; granulocyte chemotaxis; hepatocyte differentiation; inflammatory response; innate immune response; insulin secretion; keratinocyte differentiation; localization; monocyte chemotaxis; myoblast migration involved in skeletal muscle regeneration; negative regulation of apoptotic process; negative regulation of exocytosis; negative regulation of interleukin-8 production; negative regulation of phospholipase A2 activity; negative regulation of T-helper 2 cell differentiation; neutrophil activation; neutrophil clearance; neutrophil homeostasis; peptide cross-linking; phagocytosis; positive regulation of cell migration involved in sprouting angiogenesis; positive regulation of G1/S transition of mitotic cell cycle; positive regulation of interleukin-2 production; positive regulation of neutrophil apoptotic process; positive regulation of prostaglandin biosynthetic process; positive regulation of T cell proliferation; positive regulation of T-helper 1 cell differentiation; positive regulation of vesicle fusion; positive regulation of wound healing; prolactin secretion; prostate gland development; regulation of cell shape; regulation of hormone secretion; regulation of inflammatory response; regulation of interleukin-1 production; regulation of leukocyte migration; response to estradiol; response to interleukin-1; response to peptide hormone; response to X-ray; signal transduction
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Reference #:
P04083
(UniProtKB)
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Alt. Names/Synonyms: Annexin A1; Annexin I; annexin I (lipocortin I); Annexin-1; ANX1; anxa 1; ANXA1; Calpactin II; Calpactin-2; Chromobindin-9; epididymis secretory sperm binding protein; Lipocortin I; LPC1; p35; Phospholipase A2 inhibitory protein
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Gene Symbols: ANXA1
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Molecular weight:
38,714 Da
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Basal Isoelectric point:
6.57
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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