SCN11A This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant sodium channel isoform. Also involved, with the contribution of the receptor tyrosine kinase NTRK2, in rapid BDNF-evoked neuronal depolarization. Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.9/SCN11A subfamily. Expressed in the dorsal root ganglia and trigeminal ganglia, olfactory bulb, hippocampus, cerebellar cortex, spinal cord, spleen, small intestine and placenta. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of human Ortholog: 3p22.2
Cellular Component:  axon; axonal growth cone; C-fiber; neuronal cell body; voltage-gated sodium channel complex
Molecular Function:  voltage-gated ion channel activity; voltage-gated sodium channel activity
Biological Process:  action potential initiation; acute inflammatory response; artery development; axonogenesis; behavioral response to acetic acid induced pain; behavioral response to formalin induced pain; calcitonin gene-related peptide receptor signaling pathway; calcium ion transmembrane transport; cell motility; cellular response to cold; chronic inflammatory response; circadian rhythm; detection of mechanical stimulus involved in sensory perception of pain; detection of temperature stimulus involved in sensory perception of pain; mast cell degranulation; membrane depolarization during action potential; micturition; neuronal action potential; protein kinase A signaling; reflex; regulation of ion transmembrane transport; regulation of sensory perception of pain; response to auditory stimulus; response to heat; response to high light intensity; response to nitric oxide; response to prostaglandin E; response to toxic substance; response to xenobiotic stimulus; sensory perception of itch; skeletal muscle organ development; small intestine smooth muscle contraction; sodium ion transmembrane transport; sodium ion transport; thermosensory behavior; thigmotaxis
Disease: Episodic Pain Syndrome, Familial, 3; Neuropathy, Hereditary Sensory And Autonomic, Type Vii
Reference #:  Q9UI33 (UniProtKB)
Alt. Names/Synonyms: FEPS3; hNaN; HSAN7; NaN; NAV1.9; Peripheral nerve sodium channel 5; PN5; SCN11A; SCN12A; SCNBA; Sensory neuron sodium channel 2; SNS-2; SNS2; Sodium channel protein type 11 subunit alpha; Sodium channel protein type XI subunit alpha; sodium channel, voltage-gated, type XI, alpha polypeptide; sodium channel, voltage-gated, type XI, alpha subunit; sodium channel, voltage-gated, type XII, alpha polypeptide; sodium voltage-gated channel alpha subunit 11; voltage-gated sodium channel Nav1.9; Voltage-gated sodium channel subunit alpha Nav1.9
Gene Symbols: SCN11A
Molecular weight: 204,922 Da
Basal Isoelectric point: 8.32  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene