CAPNS1 Regulatory subunit of the calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Protease
Chromosomal Location of human Ortholog: 19q13.12
Cellular Component:  cytosol; membrane; plasma membrane
Molecular Function:  calcium ion binding; calcium-dependent cysteine-type endopeptidase activity; protein binding
Biological Process:  cornification; extracellular matrix disassembly; positive regulation of cell proliferation; proteolysis; regulation of macroautophagy
Reference #:  P04632 (UniProtKB)
Alt. Names/Synonyms: 30K; calcium-activated neutral proteinase; Calcium-activated neutral proteinase small subunit; Calcium-dependent protease small subunit; Calcium-dependent protease small subunit 1; calcium-dependent protease, small subunit; calpain 4, small subunit (30K); Calpain regulatory subunit; Calpain small subunit 1; calpain, small polypeptide; calpain, small subunit 1; CALPAIN4; CANP; CANP small subunit; CANPS; CAPN4; CAPNS; CAPNS1; CDPS; CPNS1; CSS1; epididymis secretory sperm binding protein
Gene Symbols: CAPNS1
Molecular weight: 28,316 Da
Basal Isoelectric point: 5.05  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein