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ALK2
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin. May be involved for left-right pattern formation during embryogenesis. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. Expressed in normal parenchymal cells, endothelial cells, fibroblasts and tumor-derived epithelial cells. Note: This description may include information from UniProtKB.
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| Protein type: EC 2.7.11.30; Kinase, protein; Membrane protein, integral; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL; STKR family; STKR1 subfamily; TKL group |
| Chromosomal Location of mouse Ortholog: 2|2 C1.1 |
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Cellular Component:
activin receptor complex; apical part of cell; BMP receptor complex; membrane; plasma membrane
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Molecular Function:
activin binding; activin receptor activity, type I; ATP binding; cadherin binding; growth factor binding; kinase activity; metal ion binding; nucleotide binding; protein binding; protein homodimerization activity; protein kinase activity; protein serine/threonine kinase activity; protein tyrosine kinase binding; SMAD binding; transferase activity; transforming growth factor beta binding; transforming growth factor beta receptor activity, type I; transmembrane receptor protein serine/threonine kinase activity
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Biological Process:
activin receptor signaling pathway; acute inflammatory response; atrial septum primum morphogenesis; atrioventricular valve morphogenesis; BMP signaling pathway; BMP signaling pathway involved in heart development; branching involved in blood vessel morphogenesis; cardiac muscle cell fate commitment; cellular response to BMP stimulus; cellular response to growth factor stimulus; determination of left/right symmetry; dorsal/ventral pattern formation; embryo development; embryonic heart tube morphogenesis; endocardial cushion cell fate commitment; endocardial cushion fusion; endocardial cushion morphogenesis; gastrulation; gastrulation with mouth forming second; germ cell development; heart development; in utero embryonic development; mesoderm development; mesoderm formation; mitral valve morphogenesis; negative regulation of activin receptor signaling pathway; negative regulation of extrinsic apoptotic signaling pathway; negative regulation of G1/S transition of mitotic cell cycle; negative regulation of signal transduction; neural crest cell migration; outflow tract septum morphogenesis; pathway-restricted SMAD protein phosphorylation; peptidyl-threonine phosphorylation; pharyngeal system development; phosphorylation; positive regulation of bone mineralization; positive regulation of cell migration; positive regulation of determination of dorsal identity; positive regulation of DNA-templated transcription; positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation; positive regulation of osteoblast differentiation; positive regulation of pathway-restricted SMAD protein phosphorylation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of transcription by RNA polymerase II; protein phosphorylation; regulation of ossification; smooth muscle cell differentiation; transforming growth factor beta receptor signaling pathway; transmembrane receptor protein serine/threonine kinase signaling pathway; urogenital system development; ventricular septum morphogenesis
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Reference #:
P37172
(UniProtKB)
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Alt. Names/Synonyms: Act; activin A receptor, type 1; Activin receptor type I; Activin receptor type-1; ACTR-I; ActRIA; Acv; Acvr; Acvr1; Acvr1a; Acvrlk2; Alk; Alk-2; ALK2; Alk8; D330013D15Rik; OTTMUSP00000013591; OTTMUSP00000013592; OTTMUSP00000013619; Serine/threonine-protein kinase receptor R1; SKR1; TGF-B superfamily receptor type I; Tgfb1; Tsk; TSK-7L; Tsk7L; TSR-I
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Gene Symbols: Acvr1
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Molecular weight:
57,226 Da
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Basal Isoelectric point:
7.12
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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