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IL6R
Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis. Low concentration of a soluble form of IL6 receptor acts as an agonist of IL6 activity. Belongs to the type I cytokine receptor family. Type 3 subfamily. Isoform 2 is expressed in peripheral blood mononuclear cells and weakly found in urine and serum. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Membrane protein, integral; Receptor, cytokine |
| Chromosomal Location of human Ortholog: 1q21.3 |
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Cellular Component:
apical plasma membrane; ciliary neurotrophic factor receptor complex; external side of plasma membrane; extracellular region; interleukin-6 receptor complex; plasma membrane; receptor complex
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Molecular Function:
ciliary neurotrophic factor binding; ciliary neurotrophic factor receptor activity; enzyme binding; interleukin-11 binding; interleukin-11 receptor activity; interleukin-6 binding; interleukin-6 receptor activity; interleukin-6 receptor binding; protein binding; protein homodimerization activity
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Biological Process:
acute-phase response; ciliary neurotrophic factor-mediated signaling pathway; cytokine-mediated signaling pathway; defense response to Gram-negative bacterium; endocrine pancreas development; extrinsic apoptotic signaling pathway; hepatic immune response; interleukin-11-mediated signaling pathway; interleukin-6-mediated signaling pathway; monocyte chemotaxis; positive regulation of activation of Janus kinase activity; positive regulation of cell population proliferation; positive regulation of chemokine production; positive regulation of glomerular mesangial cell proliferation; positive regulation of interleukin-6 production; positive regulation of leukocyte chemotaxis; positive regulation of osteoblast differentiation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of smooth muscle cell proliferation; positive regulation of tyrosine phosphorylation of STAT protein; response to cytokine; T-helper 17 cell lineage commitment; vascular endothelial growth factor production
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Disease: Hyper-ige Recurrent Infection Syndrome 5, Autosomal Recessive; Interleukin 6, Serum Level Of, Quantitative Trait Locus; Soluble Interleukin-6 Receptor, Serum Level Of, Quantitative Trait Locus
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Reference #:
P08887
(UniProtKB)
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Alt. Names/Synonyms: CD126; CD126 antigen; gp80; HIES5; IL-6 receptor subunit alpha; IL-6R 1; IL-6R subunit alpha; IL-6R-1; IL-6R-alpha; IL-6RA; IL6Q; IL6QTL; IL6R; IL6RA; IL6RQ; interleukin 6 receptor; interleukin 6 receptor alpha subunit; Interleukin-6 receptor subunit alpha; Membrane glycoprotein 80; MGC104991; sIL6R; Soluble interleukin-6 receptor subunit alpha
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Gene Symbols: IL6R
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Molecular weight:
51,548 Da
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Basal Isoelectric point:
8.56
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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