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CDK7
Serine/threonine kinase involved in cell cycle control and in RNA polymerase II-mediated RNA transcription. Cyclin-dependent kinases (CDKs) are activated by the binding to a cyclin and mediate the progression through the cell cycle. Each different complex controls a specific transition between 2 subsequent phases in the cell cycle. Required for both activation and complex formation of CDK1/cyclin-B during G2-M transition, and for activation of CDK2/cyclins during G1-S transition (but not complex formation). CDK7 is the catalytic subunit of the CDK-activating kinase (CAK) complex. Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation, thus regulating cell cycle progression. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Phosphorylation of POLR2A in complex with DNA promotes transcription initiation by triggering dissociation from DNA. Its expression and activity are constant throughout the cell cycle. Upon DNA damage, triggers p53/TP53 activation by phosphorylation, but is inactivated in turn by p53/TP53; this feedback loop may lead to an arrest of the cell cycle and of the transcription, helping in cell recovery, or to apoptosis. Required for DNA-bound peptides-mediated transcription and cellular growth inhibition. Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. Ubiquitous. Note: This description may include information from UniProtKB.
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| Protein type: CDK family; CDK/CDK7 subfamily; CDK7 subfamily; CMGC group; Cell cycle regulation; EC 2.7.11.22; EC 2.7.11.23; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) |
| Chromosomal Location of mouse Ortholog: 13 D1|13 53.23 cM |
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Cellular Component:
CAK-ERCC2 complex; cyclin-dependent protein kinase activating kinase holoenzyme complex; cytoplasm; cytosol; fibrillar center; male germ cell nucleus; nucleoplasm; nucleus; plasma membrane; transcription factor TFIIH core complex; transcription factor TFIIH holo complex; transcription factor TFIIK complex
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Molecular Function:
ATP binding; ATP-dependent activity, acting on DNA; cyclin-dependent protein serine/threonine kinase activity; kinase activity; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; protein-containing complex binding; RNA polymerase II CTD heptapeptide repeat kinase activity; transferase activity
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Biological Process:
cell cycle; cell division; DNA damage response; DNA repair; phosphorylation; positive regulation of transcription by RNA polymerase II; protein phosphorylation; protein stabilization; regulation of cyclin-dependent protein serine/threonine kinase activity; regulation of G1/S transition of mitotic cell cycle; transcription by RNA polymerase II; transcription initiation at RNA polymerase II promoter
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Reference #:
Q03147
(UniProtKB)
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Alt. Names/Synonyms: 39 kDa protein kinase; AI323415; AI528512; C230069N13; CAK; CDK-activating kinase; Cdk7; Cdkn; Cdkn7; Cell division protein kinase 7; CR4 protein kinase; Crk; CRK4; CRK4 PK (CDC2-related-kinase-4 protein kinase); Cyclin-dependent kinase 7; cyclin-dependent kinase 7 (homolog of Xenopus MO15 cdk-activating kinase); Mo15; Mpk-7; P39 Mo15; Protein-tyrosine kinase MPK-7; TFIIH basal transcription factor complex kinase subunit
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Gene Symbols: Cdk7
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Molecular weight:
38,968 Da
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Basal Isoelectric point:
8.66
Predict pI for various phosphorylation states
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CST Pathways:
G2/M DNA Damage Checkpoint
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Protein Acetylation
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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