CDK7 Serine/threonine kinase involved in cell cycle control and in RNA polymerase II-mediated RNA transcription. Cyclin-dependent kinases (CDKs) are activated by the binding to a cyclin and mediate the progression through the cell cycle. Each different complex controls a specific transition between 2 subsequent phases in the cell cycle. Required for both activation and complex formation of CDK1/cyclin-B during G2-M transition, and for activation of CDK2/cyclins during G1-S transition (but not complex formation). CDK7 is the catalytic subunit of the CDK-activating kinase (CAK) complex. Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation, thus regulating cell cycle progression. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Phosphorylation of POLR2A in complex with DNA promotes transcription initiation by triggering dissociation from DNA. Its expression and activity are constant throughout the cell cycle. Upon DNA damage, triggers p53/TP53 activation by phosphorylation, but is inactivated in turn by p53/TP53; this feedback loop may lead to an arrest of the cell cycle and of the transcription, helping in cell recovery, or to apoptosis. Required for DNA-bound peptides-mediated transcription and cellular growth inhibition. Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. Ubiquitous. Note: This description may include information from UniProtKB.
Protein type: CDK family; CDK/CDK7 subfamily; CDK7 subfamily; CMGC group; Cell cycle regulation; EC 2.7.11.22; EC 2.7.11.23; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 13 D1|13 53.23 cM
Cellular Component:  cyclin-dependent protein kinase activating kinase holoenzyme complex; cytoplasm; cytoskeleton; cytosol; membrane; nucleus; transcription factor TFIIH holo complex; transcription factor TFIIK complex
Molecular Function:  ATP binding; cyclin-dependent protein serine/threonine kinase activity; DNA-dependent ATPase activity; kinase activity; nucleotide binding; protein binding; protein C-terminus binding; protein kinase activity; protein serine/threonine kinase activity; protein-containing complex binding; RNA polymerase II CTD heptapeptide repeat kinase activity; transferase activity
Biological Process:  cell cycle; cell division; cellular response to DNA damage stimulus; DNA repair; phosphorylation; positive regulation of transcription by RNA polymerase II; protein phosphorylation; protein stabilization; transcription by RNA polymerase II
Reference #:  Q03147 (UniProtKB)
Alt. Names/Synonyms: 39 kDa protein kinase; AI323415; AI528512; C230069N13; CAK; CDK-activating kinase; Cdk7; Cdkn7; Cell division protein kinase 7; CR4 protein kinase; CRK4; CRK4 PK (CDC2-related-kinase-4 protein kinase); Cyclin-dependent kinase 7; cyclin-dependent kinase 7 (homolog of Xenopus MO15 cdk-activating kinase); Mo15; Mpk-7; P39 Mo15; Protein-tyrosine kinase MPK-7; TFIIH basal transcription factor complex kinase subunit
Gene Symbols: Cdk7
Molecular weight: 38,968 Da
Basal Isoelectric point: 8.66  Predict pI for various phosphorylation states
CST Pathways:  G2/M DNA Damage Checkpoint  |  Protein Acetylation
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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CDK7

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Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene