CDK7 a protein kinase of the CDK family. Forms a trimeric complex with cyclin H and MAT1, which functions as a Cdk-activating kinase (CAK). Activates the cyclin-associated kinases CDK1, -2, -4 and -6. An essential component of the transcription factor TFIIH, that is involved in transcription initiation and DNA repair. Serves as a direct link between the regulation of transcription and the cell cycle. Phosphorylates and activates RNA polymerase II, allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle. Note: This description may include information from UniProtKB.
Protein type: CDK family; CDK/CDK7 subfamily; CDK7 subfamily; CMGC group; Cell cycle regulation; EC; EC; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 13 D1|13 53.23 cM
Cellular Component:  cyclin-dependent protein kinase activating kinase holoenzyme complex; cytoplasm; cytoskeleton; cytosol; membrane; nucleus; transcription factor TFIIH holo complex; transcription factor TFIIK complex
Molecular Function:  ATP binding; cyclin-dependent protein serine/threonine kinase activity; DNA-dependent ATPase activity; kinase activity; nucleotide binding; protein binding; protein C-terminus binding; protein kinase activity; protein serine/threonine kinase activity; protein-containing complex binding; RNA polymerase II CTD heptapeptide repeat kinase activity; transferase activity
Biological Process:  cell cycle; cell division; cellular response to DNA damage stimulus; DNA repair; phosphorylation; positive regulation of transcription by RNA polymerase II; protein phosphorylation; protein stabilization; transcription by RNA polymerase II
Reference #:  Q03147 (UniProtKB)
Alt. Names/Synonyms: 39 kDa protein kinase; AI323415; AI528512; C230069N13; CAK; CDK-activating kinase; Cdk7; Cdkn7; Cell division protein kinase 7; CR4 protein kinase; CRK4; CRK4 PK (CDC2-related-kinase-4 protein kinase); Cyclin-dependent kinase 7; cyclin-dependent kinase 7 (homolog of Xenopus MO15 cdk-activating kinase); Mo15; Mpk-7; P39 Mo15; Protein-tyrosine kinase MPK-7; TFIIH basal transcription factor complex kinase subunit
Gene Symbols: Cdk7
Molecular weight: 38,968 Da
Basal Isoelectric point: 8.66  Predict pI for various phosphorylation states
CST Pathways:  G2/M DNA Damage Checkpoint  |  Protein Acetylation
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene