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SNCG
Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases. May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway. Belongs to the synuclein family. Highly expressed in brain, particularly in the substantia nigra. Also expressed in the corpus callosum, heart, skeletal muscle, ovary, testis, colon and spleen. Weak expression in pancreas, kidney and lung. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold |
| Chromosomal Location of human Ortholog: 10q23.2 |
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Cellular Component:
axon terminus; centrosome; cytoplasm; neuronal cell body; perinuclear region of cytoplasm; spindle
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Molecular Function:
cuprous ion binding; protein binding
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Biological Process:
adult locomotory behavior; chemical synaptic transmission; protein secretion; regulation of dopamine secretion; regulation of neuron death; regulation of neurotransmitter secretion; synapse organization; synaptic vesicle endocytosis
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Reference #:
O76070
(UniProtKB)
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Alt. Names/Synonyms: -synuclein; BCSG1; Breast cancer-specific gene 1 protein; E pound-synuclein; Gamma-synuclein; PERSYN; PRSN; SNCG; SR; Synoretin; synuclein gamma; synuclein, gamma (breast cancer-specific protein 1); SYUG
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Gene Symbols: SNCG
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Molecular weight:
13,331 Da
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Basal Isoelectric point:
4.89
Predict pI for various phosphorylation states
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