SNCG Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases. May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway. Belongs to the synuclein family. Highly expressed in brain, particularly in the substantia nigra. Also expressed in the corpus callosum, heart, skeletal muscle, ovary, testis, colon and spleen. Weak expression in pancreas, kidney and lung. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 10q23.2
Cellular Component:  axon; cytoplasm; microtubule organizing center; neuronal cell body; perinuclear region of cytoplasm; spindle
Molecular Function:  protein binding
Biological Process:  adult locomotory behavior; chemical synaptic transmission; protein secretion; regulation of dopamine secretion; regulation of neurotransmitter secretion; synapse organization
Reference #:  O76070 (UniProtKB)
Alt. Names/Synonyms: -synuclein; BCSG1; Breast cancer-specific gene 1 protein; E pound-synuclein; Gamma-synuclein; PERSYN; PRSN; SNCG; SR; Synoretin; synuclein gamma; synuclein, gamma (breast cancer-specific protein 1); SYUG
Gene Symbols: SNCG
Molecular weight: 13,331 Da
Basal Isoelectric point: 4.89  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene