|
ADA
Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. Acts as a positive regulator of T-cell coactivation, by binding DPP4. Its interaction with DPP4 regulates lymphocyte-epithelial cell adhesion. Enhances dendritic cell immunogenicity by affecting dendritic cell costimulatory molecule expression and cytokines and chemokines secretion. Enhances CD4+ T-cell differentiation and proliferation. Acts as a positive modulator of adenosine receptors ADORA1 and ADORA2A, by enhancing their ligand affinity via conformational change. Stimulates plasminogen activation. Plays a role in male fertility. Plays a protective role in early postimplantation embryonic development. Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Found in all tissues, occurs in large amounts in T-lymphocytes (PubMed:20959412). Expressed at the time of weaning in gastrointestinal tissues. Note: This description may include information from UniProtKB.
|
| Protein type: EC 3.5.4.4; Hydrolase; Nucleotide Metabolism - purine |
| Chromosomal Location of human Ortholog: 20q13.12 |
|
Cellular Component:
cell junction; cell surface; cytoplasmic vesicle lumen; cytosol; dendrite cytoplasm; external side of plasma membrane; extracellular space; lysosome; membrane; neuronal cell body; plasma membrane
|
|
Molecular Function:
adenosine deaminase activity; protein binding; purine nucleoside binding; zinc ion binding
|
|
Biological Process:
adenosine catabolic process; aging; cell adhesion; dATP catabolic process; deoxyadenosine catabolic process; embryonic digestive tract development; germinal center B cell differentiation; histamine secretion; inosine biosynthetic process; liver development; lung alveolus development; negative regulation of adenosine receptor signaling pathway; negative regulation of circadian sleep/wake cycle, non-REM sleep; negative regulation of inflammatory response; negative regulation of leukocyte migration; negative regulation of mature B cell apoptotic process; negative regulation of mucus secretion; negative regulation of penile erection; negative regulation of thymocyte apoptotic process; Peyer's patch development; placenta development; positive regulation of alpha-beta T cell differentiation; positive regulation of B cell proliferation; positive regulation of calcium-mediated signaling; positive regulation of germinal center formation; positive regulation of heart rate; positive regulation of smooth muscle contraction; positive regulation of T cell differentiation in thymus; positive regulation of T cell receptor signaling pathway; purine nucleotide salvage; purine ribonucleoside monophosphate biosynthetic process; purine-containing compound salvage; regulation of cell-cell adhesion mediated by integrin; response to hydrogen peroxide; response to hypoxia; response to morphine; response to vitamin E; T cell activation; trophectodermal cell differentiation; xanthine biosynthetic process
|
|
Disease: Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-negative, B Cell-negative, Nk Cell-negative, Due To Adenosine Deaminase Deficiency
|
|
Reference #:
P00813
(UniProtKB)
|
|
Alt. Names/Synonyms: ADA; ADA1; Adenosine aminohydrolase; Adenosine deaminase
|
|
Gene Symbols: ADA
|
|
Molecular weight:
40,764 Da
|
|
Basal Isoelectric point:
5.63
Predict pI for various phosphorylation states
|
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
|
