ADA Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. Acts as a positive regulator of T-cell coactivation, by binding DPP4. Its interaction with DPP4 regulates lymphocyte-epithelial cell adhesion. Enhances dendritic cell immunogenicity by affecting dendritic cell costimulatory molecule expression and cytokines and chemokines secretion. Enhances CD4+ T-cell differentiation and proliferation. Acts as a positive modulator of adenosine receptors ADORA1 and ADORA2A, by enhancing their ligand affinity via conformational change. Stimulates plasminogen activation. Plays a role in male fertility. Plays a protective role in early postimplantation embryonic development. Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Found in all tissues, occurs in large amounts in T-lymphocytes (PubMed:20959412). Expressed at the time of weaning in gastrointestinal tissues. Note: This description may include information from UniProtKB.
Protein type: EC 3.5.4.4; Hydrolase; Nucleotide Metabolism - purine
Chromosomal Location of human Ortholog: 20q13.12
Cellular Component:  cell junction; cell surface; cytoplasmic vesicle lumen; cytosol; dendrite cytoplasm; external side of plasma membrane; extracellular space; lysosome; membrane; neuronal cell body; plasma membrane
Molecular Function:  adenosine deaminase activity; protein binding; purine nucleoside binding; zinc ion binding
Biological Process:  adenosine catabolic process; aging; cell adhesion; dATP catabolic process; deoxyadenosine catabolic process; embryonic digestive tract development; germinal center B cell differentiation; histamine secretion; inosine biosynthetic process; liver development; lung alveolus development; negative regulation of adenosine receptor signaling pathway; negative regulation of circadian sleep/wake cycle, non-REM sleep; negative regulation of inflammatory response; negative regulation of leukocyte migration; negative regulation of mature B cell apoptotic process; negative regulation of mucus secretion; negative regulation of penile erection; negative regulation of thymocyte apoptotic process; Peyer's patch development; placenta development; positive regulation of alpha-beta T cell differentiation; positive regulation of B cell proliferation; positive regulation of calcium-mediated signaling; positive regulation of germinal center formation; positive regulation of heart rate; positive regulation of smooth muscle contraction; positive regulation of T cell differentiation in thymus; positive regulation of T cell receptor signaling pathway; purine nucleotide salvage; purine ribonucleoside monophosphate biosynthetic process; purine-containing compound salvage; regulation of cell-cell adhesion mediated by integrin; response to hydrogen peroxide; response to hypoxia; response to morphine; response to vitamin E; T cell activation; trophectodermal cell differentiation; xanthine biosynthetic process
Disease: Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-negative, B Cell-negative, Nk Cell-negative, Due To Adenosine Deaminase Deficiency
Reference #:  P00813 (UniProtKB)
Alt. Names/Synonyms: ADA; ADA1; Adenosine aminohydrolase; Adenosine deaminase
Gene Symbols: ADA
Molecular weight: 40,764 Da
Basal Isoelectric point: 5.63  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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ADA

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene