| METTL14 The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some mRNAs and regulates the circadian clock, differentiation of embryonic stem cells and cortical neurogenesis. In the heterodimer formed with METTL3, METTL14 constitutes the RNA-binding scaffold that recognizes the substrate rather than the catalytic core. N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability and processing. M6A acts as a key regulator of mRNA stability by promoting mRNA destabilization and degradation. In embryonic stem cells (ESCs), m6A methylation of mRNAs encoding key naive pluripotency-promoting transcripts results in transcript destabilization. M6A regulates spermatogonial differentiation and meiosis and is essential for male fertility and spermatogenesis. M6A also regulates cortical neurogenesis: m6A methylation of transcripts related to transcription factors, neural stem cells, the cell cycle and neuronal differentiation during brain development promotes their destabilization and decay, promoting differentiation of radial glial cells. Belongs to the MT-A70-like family. Note: This description may include information from UniProtKB. |
| Protein type: EC 2.1.1.62; Methyltransferase |
| Chromosomal Location of human Ortholog: 4q26 |
| Cellular Component: nucleoplasm; nucleus; RNA N6-methyladenosine methyltransferase complex |
| Molecular Function: mRNA (N6-adenosine)-methyltransferase activity; mRNA binding; protein binding; S-adenosyl-L-methionine binding |
| Biological Process: forebrain radial glial cell differentiation; gliogenesis; mRNA catabolic process; mRNA destabilization; mRNA methylation; mRNA splicing, via spliceosome; negative regulation of hematopoietic progenitor cell differentiation; positive regulation of translation; regulation of neuron differentiation; spermatogenesis; stem cell population maintenance |
| Reference #: Q9HCE5 (UniProtKB) |
| Alt. Names/Synonyms: hMETTL14; KIAA1627; MET14; methyltransferase like 14; Methyltransferase-like protein 14; METTL14; MTL14; N6-adenosine-methyltransferase non-catalytic subunit; N6-adenosine-methyltransferase subunit METTL14 |
| Gene Symbols: METTL14 |
| Molecular weight: 52,150 Da |
| Basal Isoelectric point: 5.89 Predict pI for various phosphorylation states |
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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METTL14 |
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STRING
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cBioPortal
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Wikipedia
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neXtProt
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Protein Atlas
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BioGPS
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Pfam
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