AKAP7 Probably targets cAMP-dependent protein kinase (PKA) to the cellular membrane or cytoskeletal structures. The membrane-associated form reduces epithelial sodium channel (ENaC) activity, whereas the free cytoplasmic form may negatively regulate ENaC channel feedback inhibition by intracellular sodium. Expressed in brain, heart, lung, pancreas and placenta. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 6q23.2
Cellular Component:  cytosol; hippocampal mossy fiber to CA3 synapse; nucleus; protein-containing complex
Molecular Function:  nucleotide binding; protein binding; protein kinase A binding; protein kinase binding
Biological Process:  modulation of chemical synaptic transmission
Reference #:  Q9P0M2 (UniProtKB)
Alt. Names/Synonyms: A kinase (PRKA) anchor protein 7; A-kinase anchor protein 18 kDa; A-kinase anchor protein 7 isoform alpha; A-kinase anchor protein 7 isoform gamma; A-kinase anchor protein 7 isoforms alpha and beta; A-kinase anchor protein 7, isoform alpha; A-kinase anchor protein 9 kDa; A-kinase anchor protein, 18-kD; A-kinase anchoring protein 18; AKA7G; AKAP 18; AKAP-7 isoform gamma; AKAP-7 isoforms alpha and beta; AKAP18; AKAP7; protein kinase A anchoring protein 7; Protein kinase A-anchoring protein 7 isoform gamma; protein kinase A-anchoring protein 7 isoforms alpha/beta
Gene Symbols: AKAP7
Molecular weight: 39,518 Da
Basal Isoelectric point: 5.85  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene